Cargando…
Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors
SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (HDAC) inhibitor approved by the US Food and Drug Administration (FDA). SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes. I...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211306/ https://www.ncbi.nlm.nih.gov/pubmed/25371703 http://dx.doi.org/10.1155/2014/867289 |
_version_ | 1782341549416251392 |
---|---|
author | Qi, Yun-feng Huang, Yan-xin Dong, Yan Zheng, Li-hua Bao, Yong-li Sun, Lu-guo Wu, Yin Yu, Chun-lei Jiang, Hong-yu Li, Yu-xin |
author_facet | Qi, Yun-feng Huang, Yan-xin Dong, Yan Zheng, Li-hua Bao, Yong-li Sun, Lu-guo Wu, Yin Yu, Chun-lei Jiang, Hong-yu Li, Yu-xin |
author_sort | Qi, Yun-feng |
collection | PubMed |
description | SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (HDAC) inhibitor approved by the US Food and Drug Administration (FDA). SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes. In particularly, SAHA induces selective apoptosis of tumor cells, although the mechanism is not well understood. A series of microarray experiments was recently conducted to investigate tumor cell-selective proapoptotic transcriptional responses induced by SAHA. Based on that gene expression time series, we propose a novel framework for detailed analysis of the mechanism of tumor cell apoptosis selectively induced by SAHA. Our analyses indicated that SAHA selectively disrupted the DNA damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis. Our results suggest a possible regulation network. Our research extends the existing research. |
format | Online Article Text |
id | pubmed-4211306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42113062014-11-04 Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors Qi, Yun-feng Huang, Yan-xin Dong, Yan Zheng, Li-hua Bao, Yong-li Sun, Lu-guo Wu, Yin Yu, Chun-lei Jiang, Hong-yu Li, Yu-xin Comput Math Methods Med Research Article SAHA (suberoylanilide hydroxamic acid or vorinostat) is the first nonselective histone deacetylase (HDAC) inhibitor approved by the US Food and Drug Administration (FDA). SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes. In particularly, SAHA induces selective apoptosis of tumor cells, although the mechanism is not well understood. A series of microarray experiments was recently conducted to investigate tumor cell-selective proapoptotic transcriptional responses induced by SAHA. Based on that gene expression time series, we propose a novel framework for detailed analysis of the mechanism of tumor cell apoptosis selectively induced by SAHA. Our analyses indicated that SAHA selectively disrupted the DNA damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis. Our results suggest a possible regulation network. Our research extends the existing research. Hindawi Publishing Corporation 2014 2014-10-13 /pmc/articles/PMC4211306/ /pubmed/25371703 http://dx.doi.org/10.1155/2014/867289 Text en Copyright © 2014 Yun-feng Qi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qi, Yun-feng Huang, Yan-xin Dong, Yan Zheng, Li-hua Bao, Yong-li Sun, Lu-guo Wu, Yin Yu, Chun-lei Jiang, Hong-yu Li, Yu-xin Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title | Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title_full | Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title_fullStr | Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title_full_unstemmed | Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title_short | Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors |
title_sort | systematic analysis of time-series gene expression data on tumor cell-selective apoptotic responses to hdac inhibitors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211306/ https://www.ncbi.nlm.nih.gov/pubmed/25371703 http://dx.doi.org/10.1155/2014/867289 |
work_keys_str_mv | AT qiyunfeng systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT huangyanxin systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT dongyan systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT zhenglihua systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT baoyongli systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT sunluguo systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT wuyin systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT yuchunlei systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT jianghongyu systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors AT liyuxin systematicanalysisoftimeseriesgeneexpressiondataontumorcellselectiveapoptoticresponsestohdacinhibitors |