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Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress
Premature senescence induced by oncogenic stimuli or tumor suppressor activation plays opposing roles in tumorigenesis. Here, we propose that galectin-3, a β-galactoside-binding lectin, regulates premature senescence without oncogenic stress. We detected premature senescence, decreased Skp2, and inc...
Autores principales: | Kim, S-J, Lee, H-W, Gu Kang, H, La, S-H, Choi, Il Ju, Ro, J Y, Bresalier, R S, Song, J, Chun, K-H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211374/ https://www.ncbi.nlm.nih.gov/pubmed/24971481 http://dx.doi.org/10.1038/cdd.2014.88 |
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