Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors

Estrogen action through estrogen receptor α (ERα) is involved in the control of sexual and social behaviors in adult mammals. Alteration of ERα gene activity mediated by epigenetic mechanisms, such as histone modifications and DNA methylation, in particular brain areas appears to be crucial for dete...

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Detalles Bibliográficos
Autor principal: Matsuda, Ken Ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211403/
https://www.ncbi.nlm.nih.gov/pubmed/25389384
http://dx.doi.org/10.3389/fnins.2014.00344
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author Matsuda, Ken Ichi
author_facet Matsuda, Ken Ichi
author_sort Matsuda, Ken Ichi
collection PubMed
description Estrogen action through estrogen receptor α (ERα) is involved in the control of sexual and social behaviors in adult mammals. Alteration of ERα gene activity mediated by epigenetic mechanisms, such as histone modifications and DNA methylation, in particular brain areas appears to be crucial for determining the extents of these behaviors between the sexes and among individuals within the same sex. This review provides a summary of the epigenetic changes in the ERα gene promoter that correlate with sociosexual behaviors.
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spelling pubmed-42114032014-11-11 Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors Matsuda, Ken Ichi Front Neurosci Endocrinology Estrogen action through estrogen receptor α (ERα) is involved in the control of sexual and social behaviors in adult mammals. Alteration of ERα gene activity mediated by epigenetic mechanisms, such as histone modifications and DNA methylation, in particular brain areas appears to be crucial for determining the extents of these behaviors between the sexes and among individuals within the same sex. This review provides a summary of the epigenetic changes in the ERα gene promoter that correlate with sociosexual behaviors. Frontiers Media S.A. 2014-10-28 /pmc/articles/PMC4211403/ /pubmed/25389384 http://dx.doi.org/10.3389/fnins.2014.00344 Text en Copyright © 2014 Matsuda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Matsuda, Ken Ichi
Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title_full Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title_fullStr Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title_full_unstemmed Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title_short Epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
title_sort epigenetic changes in the estrogen receptor α gene promoter: implications in sociosexual behaviors
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211403/
https://www.ncbi.nlm.nih.gov/pubmed/25389384
http://dx.doi.org/10.3389/fnins.2014.00344
work_keys_str_mv AT matsudakenichi epigeneticchangesintheestrogenreceptoragenepromoterimplicationsinsociosexualbehaviors

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