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2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma
The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211472/ https://www.ncbi.nlm.nih.gov/pubmed/25386249 http://dx.doi.org/10.4081/dr.2010.e12 |
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author | Sokołowska-Wojdyło, Małgorzata Trzeciak, Magdalena Roszkiewicz, Jadwiga |
author_facet | Sokołowska-Wojdyło, Małgorzata Trzeciak, Magdalena Roszkiewicz, Jadwiga |
author_sort | Sokołowska-Wojdyło, Małgorzata |
collection | PubMed |
description | The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA) acts in non-Hodgkin’s lymphoma and has been used in our center for the treatment of advanced primary cutaneous T-cell lyphomas (CTCL). Here, we report on the efficacy and side effects of 2CdA in six patients with CTCL. One patient died owing to myelosuppression. Partial responses were seen in four cases but full remission was observed in only one case. We concluded that 2CdA has a limited usefulness in the management of advanced CTCL. |
format | Online Article Text |
id | pubmed-4211472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-42114722014-11-10 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma Sokołowska-Wojdyło, Małgorzata Trzeciak, Magdalena Roszkiewicz, Jadwiga Dermatol Reports Article The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA) acts in non-Hodgkin’s lymphoma and has been used in our center for the treatment of advanced primary cutaneous T-cell lyphomas (CTCL). Here, we report on the efficacy and side effects of 2CdA in six patients with CTCL. One patient died owing to myelosuppression. Partial responses were seen in four cases but full remission was observed in only one case. We concluded that 2CdA has a limited usefulness in the management of advanced CTCL. PAGEPress Publications 2010-09-02 /pmc/articles/PMC4211472/ /pubmed/25386249 http://dx.doi.org/10.4081/dr.2010.e12 Text en ©Copyright M. Sokołowska-Wojdyło et al., 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy |
spellingShingle | Article Sokołowska-Wojdyło, Małgorzata Trzeciak, Magdalena Roszkiewicz, Jadwiga 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title | 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title_full | 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title_fullStr | 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title_full_unstemmed | 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title_short | 2-Chlorodeoxyadenosine treatment for cutaneous T-cell lymphoma |
title_sort | 2-chlorodeoxyadenosine treatment for cutaneous t-cell lymphoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211472/ https://www.ncbi.nlm.nih.gov/pubmed/25386249 http://dx.doi.org/10.4081/dr.2010.e12 |
work_keys_str_mv | AT sokołowskawojdyłomałgorzata 2chlorodeoxyadenosinetreatmentforcutaneoustcelllymphoma AT trzeciakmagdalena 2chlorodeoxyadenosinetreatmentforcutaneoustcelllymphoma AT roszkiewiczjadwiga 2chlorodeoxyadenosinetreatmentforcutaneoustcelllymphoma |