A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

This Phase 1, randomized, two-site (United States), double-blind, placebo-controlled study enrolled 18 sexually abstinent men and women. All received a single 300-mg dose of oral tenofovir disoproxil fumarate (TDF) and were then randomized 2∶1 to receive single and then seven daily rectal exposures...

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Detalles Bibliográficos
Autores principales: Yang, Kuo-Hsiung, Hendrix, Craig, Bumpus, Namandje, Elliott, Julie, Tanner, Karen, Mauck, Christine, Cranston, Ross, McGowan, Ian, Richardson-Harman, Nicola, Anton, Peter A., Kashuba, Angela D. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211672/
https://www.ncbi.nlm.nih.gov/pubmed/25350119
http://dx.doi.org/10.1371/journal.pone.0106196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211672/
https://www.ncbi.nlm.nih.gov/pubmed/25350119
http://dx.doi.org/10.1371/journal.pone.0106196

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