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Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy

BACKGROUND: Toxoplasmosis, one of the most common zoonotic diseases worldwide, can induce various hormonal and behavioural alterations in infected hosts, and its most common form, latent toxoplasmosis, influences the course of pregnancy. Autoimmune thyroid diseases (AITD) belong to the well-defined...

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Autores principales: Kaňková, Šárka, Procházková, Lucie, Flegr, Jaroslav, Calda, Pavel, Springer, Drahomíra, Potluková, Eliška
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211690/
https://www.ncbi.nlm.nih.gov/pubmed/25350671
http://dx.doi.org/10.1371/journal.pone.0110878
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author Kaňková, Šárka
Procházková, Lucie
Flegr, Jaroslav
Calda, Pavel
Springer, Drahomíra
Potluková, Eliška
author_facet Kaňková, Šárka
Procházková, Lucie
Flegr, Jaroslav
Calda, Pavel
Springer, Drahomíra
Potluková, Eliška
author_sort Kaňková, Šárka
collection PubMed
description BACKGROUND: Toxoplasmosis, one of the most common zoonotic diseases worldwide, can induce various hormonal and behavioural alterations in infected hosts, and its most common form, latent toxoplasmosis, influences the course of pregnancy. Autoimmune thyroid diseases (AITD) belong to the well-defined risk factors for adverse pregnancy outcomes. The aim of this study was to investigate whether there is a link between latent toxoplasmosis and maternal AITD in pregnancy. METHODS: Cross-sectional study in 1248 consecutive pregnant women in the 9–12(th) gestational weeks. Serum thyroid-stimulating hormone (TSH), thyroperoxidase antibodies (TPOAb), and free thyroxine (FT4) were assessed by chemiluminescence; the Toxoplasma status was detected by the complement fixation test (CFT) and anti-Toxoplasma IgG enzyme-linked immunosorbent assay (ELISA). RESULTS: Overall, 22.5% of the women were positive for latent toxoplasmosis and 14.7% were screened positive for AITD. Women with latent toxoplasmosis had more often highly elevated TPOAb than the Toxoplasma-negative ones (p = 0.004), and latent toxoplasmosis was associated with decrease in serum TSH levels (p = 0.049). Moreover, we found a positive correlation between FT4 and the index of positivity for anti-Toxoplasma IgG antibodies (p = 0.033), which was even stronger in the TPOAb-positive Toxoplasma-positive women, (p = 0.014), as well as a positive correlation between FT4 and log(2) CFT (p = 0.009). CONCLUSIONS: Latent toxoplasmosis was associated with a mild increase in thyroid hormone production in pregnancy. The observed Toxoplasma-associated changes in the parameters of AITD are mild and do not seem to be clinically relevant; however, they could provide new clues to the complex pathogenesis of autoimmune thyroid diseases.
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spelling pubmed-42116902014-11-05 Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy Kaňková, Šárka Procházková, Lucie Flegr, Jaroslav Calda, Pavel Springer, Drahomíra Potluková, Eliška PLoS One Research Article BACKGROUND: Toxoplasmosis, one of the most common zoonotic diseases worldwide, can induce various hormonal and behavioural alterations in infected hosts, and its most common form, latent toxoplasmosis, influences the course of pregnancy. Autoimmune thyroid diseases (AITD) belong to the well-defined risk factors for adverse pregnancy outcomes. The aim of this study was to investigate whether there is a link between latent toxoplasmosis and maternal AITD in pregnancy. METHODS: Cross-sectional study in 1248 consecutive pregnant women in the 9–12(th) gestational weeks. Serum thyroid-stimulating hormone (TSH), thyroperoxidase antibodies (TPOAb), and free thyroxine (FT4) were assessed by chemiluminescence; the Toxoplasma status was detected by the complement fixation test (CFT) and anti-Toxoplasma IgG enzyme-linked immunosorbent assay (ELISA). RESULTS: Overall, 22.5% of the women were positive for latent toxoplasmosis and 14.7% were screened positive for AITD. Women with latent toxoplasmosis had more often highly elevated TPOAb than the Toxoplasma-negative ones (p = 0.004), and latent toxoplasmosis was associated with decrease in serum TSH levels (p = 0.049). Moreover, we found a positive correlation between FT4 and the index of positivity for anti-Toxoplasma IgG antibodies (p = 0.033), which was even stronger in the TPOAb-positive Toxoplasma-positive women, (p = 0.014), as well as a positive correlation between FT4 and log(2) CFT (p = 0.009). CONCLUSIONS: Latent toxoplasmosis was associated with a mild increase in thyroid hormone production in pregnancy. The observed Toxoplasma-associated changes in the parameters of AITD are mild and do not seem to be clinically relevant; however, they could provide new clues to the complex pathogenesis of autoimmune thyroid diseases. Public Library of Science 2014-10-28 /pmc/articles/PMC4211690/ /pubmed/25350671 http://dx.doi.org/10.1371/journal.pone.0110878 Text en © 2014 Kaňková et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kaňková, Šárka
Procházková, Lucie
Flegr, Jaroslav
Calda, Pavel
Springer, Drahomíra
Potluková, Eliška
Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title_full Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title_fullStr Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title_full_unstemmed Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title_short Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy
title_sort effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211690/
https://www.ncbi.nlm.nih.gov/pubmed/25350671
http://dx.doi.org/10.1371/journal.pone.0110878
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