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Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia

Glioblastoma multiforme (GBM) is the most common and lethal form of brain cancer and these tumors are highly resistant to chemo- and radiotherapy. Radioresistance is thought to result from a paucity of molecular oxygen in hypoxic tumor regions, resulting in reduced DNA damage and enhanced cellular d...

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Detalles Bibliográficos
Autores principales:	Clarke, Ryon H., Moosa, Shayan, Anzivino, Matthew, Wang, Yi, Floyd, Desiree Hunt, Purow, Benjamin W., Lee, Kevin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211739/ https://www.ncbi.nlm.nih.gov/pubmed/25350400 http://dx.doi.org/10.1371/journal.pone.0111199

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