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Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood–brain barrier

Methotrexate (MTX) is the single most effective agent for the treatment of primary central nervous system lymphoma. Currently, the delivery of MTX to the brain is achieved by high systemic doses, which cause severe long-term neurotoxicity, or intrathecal administration, which is highly invasive and...

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Detalles Bibliográficos
Autores principales:	Wang, Xiang, Liu, Ping, Yang, Weixiao, Li, Lu, Li, Peijing, Liu, Zheng, Zhuo, Zhongxiong, Gao, Yunhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211917/ https://www.ncbi.nlm.nih.gov/pubmed/25364248 http://dx.doi.org/10.2147/IJN.S69845

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