Regulatory T Cells in B Cell Follicles

Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of therapeutic intervention for the treatment of antibody-mediated immune disorders. Recent advances in this field have revealed...

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Detalles Bibliográficos
Autores principales: Chang, Jae-Hoon, Chung, Yeonseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212083/
https://www.ncbi.nlm.nih.gov/pubmed/25360073
http://dx.doi.org/10.4110/in.2014.14.5.227
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author Chang, Jae-Hoon
Chung, Yeonseok
author_facet Chang, Jae-Hoon
Chung, Yeonseok
author_sort Chang, Jae-Hoon
collection PubMed
description Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of therapeutic intervention for the treatment of antibody-mediated immune disorders. Recent advances in this field have revealed specialized subsets of T cells necessary for the control of B cell responses in the follicle. These cells include follicular regulatory T cells and Qa-1-restricted cluster of differentiation (CD)8(+) regulatory T cells. In this review, we discuss the current knowledge related to the role of regulatory T cells in the B cell follicle.
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spelling pubmed-42120832014-10-30 Regulatory T Cells in B Cell Follicles Chang, Jae-Hoon Chung, Yeonseok Immune Netw Review Article Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of therapeutic intervention for the treatment of antibody-mediated immune disorders. Recent advances in this field have revealed specialized subsets of T cells necessary for the control of B cell responses in the follicle. These cells include follicular regulatory T cells and Qa-1-restricted cluster of differentiation (CD)8(+) regulatory T cells. In this review, we discuss the current knowledge related to the role of regulatory T cells in the B cell follicle. The Korean Association of Immunologists 2014-10 2014-10-22 /pmc/articles/PMC4212083/ /pubmed/25360073 http://dx.doi.org/10.4110/in.2014.14.5.227 Text en Copyright © 2014 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chang, Jae-Hoon
Chung, Yeonseok
Regulatory T Cells in B Cell Follicles
title Regulatory T Cells in B Cell Follicles
title_full Regulatory T Cells in B Cell Follicles
title_fullStr Regulatory T Cells in B Cell Follicles
title_full_unstemmed Regulatory T Cells in B Cell Follicles
title_short Regulatory T Cells in B Cell Follicles
title_sort regulatory t cells in b cell follicles
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212083/
https://www.ncbi.nlm.nih.gov/pubmed/25360073
http://dx.doi.org/10.4110/in.2014.14.5.227
work_keys_str_mv AT changjaehoon regulatorytcellsinbcellfollicles
AT chungyeonseok regulatorytcellsinbcellfollicles

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