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Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study

INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently rema...

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Autores principales: Okamoto, Hidehiko, Kakigi, Ryusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212114/
https://www.ncbi.nlm.nih.gov/pubmed/25365810
http://dx.doi.org/10.1002/brb3.290
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author Okamoto, Hidehiko
Kakigi, Ryusuke
author_facet Okamoto, Hidehiko
Kakigi, Ryusuke
author_sort Okamoto, Hidehiko
collection PubMed
description INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently remains unknown whether this decrement occurs with a repetition of silences, which do not induce refractoriness. METHODS: In the present study, we investigated decrements in N1m responses elicited by five repetitive silences in a continuous pure tone and by five repetitive pure tones in silence using magnetoencephalography. RESULTS: Repetitive sound stimulation differentially affected the N1m decrement in a sound type-dependent manner; while the N1m amplitude decreased from the 1st to the 2nd pure tone and remained constant from the 2nd to the 5th pure tone in silence, a gradual decrement was observed in the N1m amplitude from the 1st to the 5th silence embedded in a continuous pure tone. CONCLUSIONS: Our results suggest that neural refractoriness may mainly cause decrements in N1m responses elicited by trains of pure tones in silence, while habituation, which is a form of the implicit learning process, may play an important role in the N1m source strength decrements elicited by successive silences in a continuous pure tone.
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spelling pubmed-42121142014-10-30 Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study Okamoto, Hidehiko Kakigi, Ryusuke Brain Behav Original Research INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently remains unknown whether this decrement occurs with a repetition of silences, which do not induce refractoriness. METHODS: In the present study, we investigated decrements in N1m responses elicited by five repetitive silences in a continuous pure tone and by five repetitive pure tones in silence using magnetoencephalography. RESULTS: Repetitive sound stimulation differentially affected the N1m decrement in a sound type-dependent manner; while the N1m amplitude decreased from the 1st to the 2nd pure tone and remained constant from the 2nd to the 5th pure tone in silence, a gradual decrement was observed in the N1m amplitude from the 1st to the 5th silence embedded in a continuous pure tone. CONCLUSIONS: Our results suggest that neural refractoriness may mainly cause decrements in N1m responses elicited by trains of pure tones in silence, while habituation, which is a form of the implicit learning process, may play an important role in the N1m source strength decrements elicited by successive silences in a continuous pure tone. BlackWell Publishing Ltd 2014-11 2014-09-30 /pmc/articles/PMC4212114/ /pubmed/25365810 http://dx.doi.org/10.1002/brb3.290 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Okamoto, Hidehiko
Kakigi, Ryusuke
Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title_full Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title_fullStr Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title_full_unstemmed Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title_short Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
title_sort neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212114/
https://www.ncbi.nlm.nih.gov/pubmed/25365810
http://dx.doi.org/10.1002/brb3.290
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