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Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study
INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently rema...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212114/ https://www.ncbi.nlm.nih.gov/pubmed/25365810 http://dx.doi.org/10.1002/brb3.290 |
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author | Okamoto, Hidehiko Kakigi, Ryusuke |
author_facet | Okamoto, Hidehiko Kakigi, Ryusuke |
author_sort | Okamoto, Hidehiko |
collection | PubMed |
description | INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently remains unknown whether this decrement occurs with a repetition of silences, which do not induce refractoriness. METHODS: In the present study, we investigated decrements in N1m responses elicited by five repetitive silences in a continuous pure tone and by five repetitive pure tones in silence using magnetoencephalography. RESULTS: Repetitive sound stimulation differentially affected the N1m decrement in a sound type-dependent manner; while the N1m amplitude decreased from the 1st to the 2nd pure tone and remained constant from the 2nd to the 5th pure tone in silence, a gradual decrement was observed in the N1m amplitude from the 1st to the 5th silence embedded in a continuous pure tone. CONCLUSIONS: Our results suggest that neural refractoriness may mainly cause decrements in N1m responses elicited by trains of pure tones in silence, while habituation, which is a form of the implicit learning process, may play an important role in the N1m source strength decrements elicited by successive silences in a continuous pure tone. |
format | Online Article Text |
id | pubmed-4212114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42121142014-10-30 Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study Okamoto, Hidehiko Kakigi, Ryusuke Brain Behav Original Research INTRODUCTION: Previous studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently remains unknown whether this decrement occurs with a repetition of silences, which do not induce refractoriness. METHODS: In the present study, we investigated decrements in N1m responses elicited by five repetitive silences in a continuous pure tone and by five repetitive pure tones in silence using magnetoencephalography. RESULTS: Repetitive sound stimulation differentially affected the N1m decrement in a sound type-dependent manner; while the N1m amplitude decreased from the 1st to the 2nd pure tone and remained constant from the 2nd to the 5th pure tone in silence, a gradual decrement was observed in the N1m amplitude from the 1st to the 5th silence embedded in a continuous pure tone. CONCLUSIONS: Our results suggest that neural refractoriness may mainly cause decrements in N1m responses elicited by trains of pure tones in silence, while habituation, which is a form of the implicit learning process, may play an important role in the N1m source strength decrements elicited by successive silences in a continuous pure tone. BlackWell Publishing Ltd 2014-11 2014-09-30 /pmc/articles/PMC4212114/ /pubmed/25365810 http://dx.doi.org/10.1002/brb3.290 Text en © 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Okamoto, Hidehiko Kakigi, Ryusuke Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title | Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title_full | Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title_fullStr | Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title_full_unstemmed | Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title_short | Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
title_sort | neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212114/ https://www.ncbi.nlm.nih.gov/pubmed/25365810 http://dx.doi.org/10.1002/brb3.290 |
work_keys_str_mv | AT okamotohidehiko neuraladaptationtosilenceinthehumanauditorycortexamagnetoencephalographicstudy AT kakigiryusuke neuraladaptationtosilenceinthehumanauditorycortexamagnetoencephalographicstudy |