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Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

BACKGROUND: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of...

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Detalles Bibliográficos
Autores principales:	Terheggen, Ulrich, Drew, Damien R, Hodder, Anthony N, Cross, Nadia J, Mugyenyi, Cleopatra K, Barry, Alyssa E, Anders, Robin F, Dutta, Sheetij, Osier, Faith HA, Elliott, Salenna R, Senn, Nicolas, Stanisic, Danielle I, Marsh, Kevin, Siba, Peter M, Mueller, Ivo, Richards, Jack S, Beeson, James G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212128/ https://www.ncbi.nlm.nih.gov/pubmed/25319190 http://dx.doi.org/10.1186/s12916-014-0183-5

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