Metastasis is regulated via microRNA-200/ZEB1 axis control of tumor cell PD-L1 expression and intratumoral immunosuppression

Immunosuppression of tumor-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mesenchymal transition (EMT) and CD8(+) TIL immunosuppression, two key drivers of cancer progres...

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Detalles Bibliográficos
Autores principales: Chen, Limo, Gibbons, Don L., Goswami, Sangeeta, Cortez, Maria Angelica, Ahn, Young-Ho, Byers, Lauren A., Zhang, Xuejun, Yi, Xiaohui, Dwyer, David, Lin, Wei, Diao, Lixia, Wang, Jing, Roybal, Jonathon, Patel, Mayuri, Ungewiss, Christin, Peng, David, Antonia, Scott, Mediavilla-Varela, Melanie, Robertson, Gordon, Suraokar, Milind, Welsh, James W., Erez, Baruch, Wistuba, Ignacio I., Chen, Lieping, Peng, Di, Wang, Shanshan, Ullrich, Stephen E., Heymach, John V., Kurie, Jonathan M., Qin, F. Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212319/
https://www.ncbi.nlm.nih.gov/pubmed/25348003
http://dx.doi.org/10.1038/ncomms6241

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