At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology

Cdk5 has been implicated in a multitude of processes in neuronal development, cell biology and physiology. These influence many neurological disorders, but the very breadth of Cdk5 effects has made it difficult to synthesize a coherent picture of the part played by this protein in health and disease...

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Detalles Bibliográficos
Autores principales: McLinden, Kristina A., Trunova, Svetlana, Giniger, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212508/
https://www.ncbi.nlm.nih.gov/pubmed/25364642
http://dx.doi.org/10.4172/2168-975X.S1-001
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author McLinden, Kristina A.
Trunova, Svetlana
Giniger, Edward
author_facet McLinden, Kristina A.
Trunova, Svetlana
Giniger, Edward
author_sort McLinden, Kristina A.
collection PubMed
description Cdk5 has been implicated in a multitude of processes in neuronal development, cell biology and physiology. These influence many neurological disorders, but the very breadth of Cdk5 effects has made it difficult to synthesize a coherent picture of the part played by this protein in health and disease. In this review, we focus on the roles of Cdk5 in neuronal function, particularly synaptic homeostasis, plasticity, neurotransmission, subcellular organization, and trafficking. We then discuss how disruption of these Cdk5 activities may initiate or exacerbate neural disorders. A recurring theme will be the sensitivity of Cdk5 sequelae to the precise biological context under consideration.
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spelling pubmed-42125082014-10-29 At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology McLinden, Kristina A. Trunova, Svetlana Giniger, Edward Brain Disord Ther Article Cdk5 has been implicated in a multitude of processes in neuronal development, cell biology and physiology. These influence many neurological disorders, but the very breadth of Cdk5 effects has made it difficult to synthesize a coherent picture of the part played by this protein in health and disease. In this review, we focus on the roles of Cdk5 in neuronal function, particularly synaptic homeostasis, plasticity, neurotransmission, subcellular organization, and trafficking. We then discuss how disruption of these Cdk5 activities may initiate or exacerbate neural disorders. A recurring theme will be the sensitivity of Cdk5 sequelae to the precise biological context under consideration. 2012-07 /pmc/articles/PMC4212508/ /pubmed/25364642 http://dx.doi.org/10.4172/2168-975X.S1-001 Text en Copyright: © 2012 McLinden KA, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
McLinden, Kristina A.
Trunova, Svetlana
Giniger, Edward
At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title_full At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title_fullStr At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title_full_unstemmed At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title_short At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
title_sort at the fulcrum in health and disease: cdk5 and the balancing acts of neuronal structure and physiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212508/
https://www.ncbi.nlm.nih.gov/pubmed/25364642
http://dx.doi.org/10.4172/2168-975X.S1-001
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