Cargando…

Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes

OBJECTIVE: Inflammatory processes may play an important role in the development of acute coronary syndromes in people with type 2 diabetes; thus, strategies to control inflammation are of clinical importance. We examined the cross-sectional association between objectively assessed physical activity...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamer, Mark, Hackett, Ruth A, Bostock, Sophie, Lazzarino, Antonio I, Carvalho, Livia A, Steptoe, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212571/
https://www.ncbi.nlm.nih.gov/pubmed/25452870
http://dx.doi.org/10.1136/bmjdrc-2014-000030
_version_ 1782341719600136192
author Hamer, Mark
Hackett, Ruth A
Bostock, Sophie
Lazzarino, Antonio I
Carvalho, Livia A
Steptoe, Andrew
author_facet Hamer, Mark
Hackett, Ruth A
Bostock, Sophie
Lazzarino, Antonio I
Carvalho, Livia A
Steptoe, Andrew
author_sort Hamer, Mark
collection PubMed
description OBJECTIVE: Inflammatory processes may play an important role in the development of acute coronary syndromes in people with type 2 diabetes; thus, strategies to control inflammation are of clinical importance. We examined the cross-sectional association between objectively assessed physical activity and inflammatory markers in a sample of people with type 2 diabetes. METHODS: Participants were 71 men and 41 women (mean age=63.9±7 years), without a history of cardiovascular disease, drawn from primary care clinics. Physical activity was objectively measured using waist-worn accelerometers (Actigraph GT3X) during waking hours for seven consecutive days. RESULTS: We observed inverse associations between moderate-to-vigorous physical activity (per 10 min) with plasma interleukin-6 (B=−0.035, 95% CI −0.056 to −0.015), interleukin-1ra (B=−0.033, 95% CI −0.051 to −0.015), and monocyte chemotactic protein-1 (B=−0.011, 95% CI −0.021 to 0.000). These associations largely persisted in multivariable adjusted models, although body mass index considerably attenuated the effect estimate. CONCLUSIONS: These data demonstrate an inverse association between physical activity and inflammatory markers in people with type 2 diabetes.
format Online
Article
Text
id pubmed-4212571
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-42125712014-12-01 Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes Hamer, Mark Hackett, Ruth A Bostock, Sophie Lazzarino, Antonio I Carvalho, Livia A Steptoe, Andrew BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk OBJECTIVE: Inflammatory processes may play an important role in the development of acute coronary syndromes in people with type 2 diabetes; thus, strategies to control inflammation are of clinical importance. We examined the cross-sectional association between objectively assessed physical activity and inflammatory markers in a sample of people with type 2 diabetes. METHODS: Participants were 71 men and 41 women (mean age=63.9±7 years), without a history of cardiovascular disease, drawn from primary care clinics. Physical activity was objectively measured using waist-worn accelerometers (Actigraph GT3X) during waking hours for seven consecutive days. RESULTS: We observed inverse associations between moderate-to-vigorous physical activity (per 10 min) with plasma interleukin-6 (B=−0.035, 95% CI −0.056 to −0.015), interleukin-1ra (B=−0.033, 95% CI −0.051 to −0.015), and monocyte chemotactic protein-1 (B=−0.011, 95% CI −0.021 to 0.000). These associations largely persisted in multivariable adjusted models, although body mass index considerably attenuated the effect estimate. CONCLUSIONS: These data demonstrate an inverse association between physical activity and inflammatory markers in people with type 2 diabetes. BMJ Publishing Group 2014-06-13 /pmc/articles/PMC4212571/ /pubmed/25452870 http://dx.doi.org/10.1136/bmjdrc-2014-000030 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Cardiovascular and Metabolic Risk
Hamer, Mark
Hackett, Ruth A
Bostock, Sophie
Lazzarino, Antonio I
Carvalho, Livia A
Steptoe, Andrew
Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title_full Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title_fullStr Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title_full_unstemmed Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title_short Objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
title_sort objectively assessed physical activity, adiposity, and inflammatory markers in people with type 2 diabetes
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212571/
https://www.ncbi.nlm.nih.gov/pubmed/25452870
http://dx.doi.org/10.1136/bmjdrc-2014-000030
work_keys_str_mv AT hamermark objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes
AT hackettrutha objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes
AT bostocksophie objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes
AT lazzarinoantonioi objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes
AT carvalholiviaa objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes
AT steptoeandrew objectivelyassessedphysicalactivityadiposityandinflammatorymarkersinpeoplewithtype2diabetes