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Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain function and behavior. In this hypothesis and theory article, we pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212686/ https://www.ncbi.nlm.nih.gov/pubmed/25401092 http://dx.doi.org/10.3389/fcimb.2014.00147 |
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author | Stilling, Roman M. Bordenstein, Seth R. Dinan, Timothy G. Cryan, John F. |
author_facet | Stilling, Roman M. Bordenstein, Seth R. Dinan, Timothy G. Cryan, John F. |
author_sort | Stilling, Roman M. |
collection | PubMed |
description | The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain function and behavior. In this hypothesis and theory article, we propose how host-microbe associations potentially influenced mammalian brain evolution and development. In particular, we explore the integration of human brain development with evolution, symbiosis, and RNA biology, which together represent a “social triangle” that drives human social behavior and cognition. We argue that, in order to understand how inter-kingdom communication can affect brain adaptation and plasticity, it is inevitable to consider epigenetic mechanisms as important mediators of genome-microbiome interactions on an individual as well as a transgenerational time scale. Finally, we unite these interpretations with the hologenome theory of evolution. Taken together, we propose a tighter integration of neuroscience fields with host-associated microbiology by taking an evolutionary perspective. |
format | Online Article Text |
id | pubmed-4212686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42126862014-11-14 Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? Stilling, Roman M. Bordenstein, Seth R. Dinan, Timothy G. Cryan, John F. Front Cell Infect Microbiol Microbiology The tight association of the human body with trillions of colonizing microbes that we observe today is the result of a long evolutionary history. Only very recently have we started to understand how this symbiosis also affects brain function and behavior. In this hypothesis and theory article, we propose how host-microbe associations potentially influenced mammalian brain evolution and development. In particular, we explore the integration of human brain development with evolution, symbiosis, and RNA biology, which together represent a “social triangle” that drives human social behavior and cognition. We argue that, in order to understand how inter-kingdom communication can affect brain adaptation and plasticity, it is inevitable to consider epigenetic mechanisms as important mediators of genome-microbiome interactions on an individual as well as a transgenerational time scale. Finally, we unite these interpretations with the hologenome theory of evolution. Taken together, we propose a tighter integration of neuroscience fields with host-associated microbiology by taking an evolutionary perspective. Frontiers Media S.A. 2014-10-29 /pmc/articles/PMC4212686/ /pubmed/25401092 http://dx.doi.org/10.3389/fcimb.2014.00147 Text en Copyright © 2014 Stilling, Bordenstein, Dinan and Cryan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Stilling, Roman M. Bordenstein, Seth R. Dinan, Timothy G. Cryan, John F. Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title | Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title_full | Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title_fullStr | Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title_full_unstemmed | Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title_short | Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
title_sort | friends with social benefits: host-microbe interactions as a driver of brain evolution and development? |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212686/ https://www.ncbi.nlm.nih.gov/pubmed/25401092 http://dx.doi.org/10.3389/fcimb.2014.00147 |
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