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Anti-inflammatory Activity of Grains of Paradise (Aframomum melegueta Schum) Extract
[Image: see text] The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided frac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212708/ https://www.ncbi.nlm.nih.gov/pubmed/25293633 http://dx.doi.org/10.1021/jf5026086 |
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author | Ilic, Nebojsa M. Dey, Moul Poulev, Alexander A. Logendra, Sithes Kuhn, Peter E. Raskin, Ilya |
author_facet | Ilic, Nebojsa M. Dey, Moul Poulev, Alexander A. Logendra, Sithes Kuhn, Peter E. Raskin, Ilya |
author_sort | Ilic, Nebojsa M. |
collection | PubMed |
description | [Image: see text] The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes. |
format | Online Article Text |
id | pubmed-4212708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42127082015-10-08 Anti-inflammatory Activity of Grains of Paradise (Aframomum melegueta Schum) Extract Ilic, Nebojsa M. Dey, Moul Poulev, Alexander A. Logendra, Sithes Kuhn, Peter E. Raskin, Ilya J Agric Food Chem [Image: see text] The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes. American Chemical Society 2014-10-08 2014-10-29 /pmc/articles/PMC4212708/ /pubmed/25293633 http://dx.doi.org/10.1021/jf5026086 Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
spellingShingle | Ilic, Nebojsa M. Dey, Moul Poulev, Alexander A. Logendra, Sithes Kuhn, Peter E. Raskin, Ilya Anti-inflammatory Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title | Anti-inflammatory
Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title_full | Anti-inflammatory
Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title_fullStr | Anti-inflammatory
Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title_full_unstemmed | Anti-inflammatory
Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title_short | Anti-inflammatory
Activity of Grains of Paradise (Aframomum melegueta Schum) Extract |
title_sort | anti-inflammatory
activity of grains of paradise (aframomum melegueta schum) extract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212708/ https://www.ncbi.nlm.nih.gov/pubmed/25293633 http://dx.doi.org/10.1021/jf5026086 |
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