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Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart
[Image: see text] The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212726/ https://www.ncbi.nlm.nih.gov/pubmed/25233037 http://dx.doi.org/10.1021/nn503693h |
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author | Pok, Seokwon Vitale, Flavia Eichmann, Shannon L. Benavides, Omar M. Pasquali, Matteo Jacot, Jeffrey G. |
author_facet | Pok, Seokwon Vitale, Flavia Eichmann, Shannon L. Benavides, Omar M. Pasquali, Matteo Jacot, Jeffrey G. |
author_sort | Pok, Seokwon |
collection | PubMed |
description | [Image: see text] The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled carbon nanotubes, on the order of tens of parts per million, incorporated in a gelatin–chitosan hydrogel act as electrical nanobridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating, and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track repair for Tetralogy of Fallot, atrial and ventricular septal defect repair, and other cardiac defects, without the risk of inducing cardiac arrhythmias. |
format | Online Article Text |
id | pubmed-4212726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42127262015-09-18 Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart Pok, Seokwon Vitale, Flavia Eichmann, Shannon L. Benavides, Omar M. Pasquali, Matteo Jacot, Jeffrey G. ACS Nano [Image: see text] The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled carbon nanotubes, on the order of tens of parts per million, incorporated in a gelatin–chitosan hydrogel act as electrical nanobridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating, and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track repair for Tetralogy of Fallot, atrial and ventricular septal defect repair, and other cardiac defects, without the risk of inducing cardiac arrhythmias. American Chemical Society 2014-09-18 2014-10-28 /pmc/articles/PMC4212726/ /pubmed/25233037 http://dx.doi.org/10.1021/nn503693h Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
spellingShingle | Pok, Seokwon Vitale, Flavia Eichmann, Shannon L. Benavides, Omar M. Pasquali, Matteo Jacot, Jeffrey G. Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title | Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title_full | Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title_fullStr | Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title_full_unstemmed | Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title_short | Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart |
title_sort | biocompatible carbon nanotube–chitosan scaffold matching the electrical conductivity of the heart |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212726/ https://www.ncbi.nlm.nih.gov/pubmed/25233037 http://dx.doi.org/10.1021/nn503693h |
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