Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) (1-3) of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age,...

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Detalles Bibliográficos
Autores principales: Wu, Chen, Wang, Zhaoming, Song, Xin, Feng, Xiao-Shan, Abnet, Christian C., He, Jie, Hu, Nan, Zuo, Xian-Bo, Tan, Wen, Zhan, Qimin, Hu, Zhibin, He, Zhonghu, Jia, Weihua, Zhou, Yifeng, Yu, Kai, Shu, Xiao-Ou, Yuan, Jian-Min, Zheng, Wei, Zhao, Xue-Ke, Gao, She-Gan, Yuan, Zhi-Qing, Zhou, Fu-You, Fan, Zong-Min, Cui, Ji-Li, Lin, Hong-Li, Han, Xue-Na, Li, Bei, Chen, Xi, Dawsey, Sanford M., Liao, Linda, Lee, Maxwell P., Ding, Ti, Qiao, You-Lin, Liu, Zhihua, Liu, Yu, Yu, Dianke, Chang, Jiang, Wei, Lixuan, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Han, Jing-Jing, Zhou, Sheng-Li, Zhang, Peng, Zhang, Dong-Yun, Yuan, Yuan, Huang, Ying, Liu, Chunling, Zhai, Kan, Qiao, Yan, Jin, Guangfu, Guo, Chuanhai, Fu, Jianhua, Miao, Xiaoping, Lu, Changdong, Yang, Haijun, Wang, Chaoyu, Wheeler, William A., Gail, Mitchell, Yeager, Meredith, Yuenger, Jeff, Guo, Er-Tao, Li, Ai-Li, Zhang, Wei, Li, Xue-Min, Sun, Liang-Dan, Ma, Bao-Gen, Li, Yan, Tang, Sa, Peng, Xiu-Qing, Liu, Jing, Hutchinson, Amy, Jacobs, Kevin, Giffen, Carol, Burdette, Laurie, Fraumeni, Joseph F., Shen, Hongbing, Ke, Yang, Zeng, Yixin, Wu, Tangchun, Kraft, Peter, Chung, Charles C., Tucker, Margaret A., Hou, Zhi-Chao, Liu, Ya-Li, Hu, Yan-Long, Wang, Li, Yuan, Guo, Chen, Li-Sha, Liu, Xiao, Ma, Teng, Meng, Hui, Sun, Li, Li, Xin-Min, Li, Xiu-Min, Ku, Jian-Wei, Zhou, Ying-Fa, Yang, Liu-Qin, Wang, Zhou, Li, Yin, Qige, Qirenwang, Yang, Wen-Jun, Lei, Guang-Yan, Chen, Long-Qi, Li, En-Min, Yuan, Ling, Yue, Wen-Bin, Wang, Ran, Wang, Lu-Wen, Fan, Xue-Ping, Zhu, Fang-Heng, Zhao, Wei-Xing, Mao, Yi-Min, Zhang, Mei, Xing, Guo-Lan, Li, Ji-Lin, Han, Min, Ren, Jing-Li, Liu, Bin, Ren, Shu-Wei, Kong, Qing-Peng, Li, Feng, Sheyhidin, Ilyar, Wei, Wu, Zhang, Yan-Rui, Feng, Chang-Wei, Wang, Jin, Yang, Yu-Hua, Hao, Hong-Zhang, Bao, Qi-De, Liu, Bao-Chi, Wu, Ai-Qun, Xie, Dong, Yang, Wan-Cai, Wang, Liang, Zhao, Xiao-Hang, Chen, Shu-Qing, Hong, Jun-Yan, Zhang, Xue-Jun, Freedman, Neal D, Goldstein, Alisa M., Lin, Dongxin, Taylor, Philip R., Wang, Li-Dong, Chanock, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212832/
https://www.ncbi.nlm.nih.gov/pubmed/25129146
http://dx.doi.org/10.1038/ng.3064
Descripción
Sumario:We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) (1-3) of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10(−20)) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10(−13)). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10(−10)). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region.

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