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Mycobacterium tuberculosis Pyrazinamide Resistance Determinants: a Multicenter Study

Pyrazinamide (PZA) is a prodrug that is converted to pyrazinoic acid by the enzyme pyrazinamidase, encoded by the pncA gene in Mycobacterium tuberculosis. Molecular identification of mutations in pncA offers the potential for rapid detection of pyrazinamide resistance (PZA(r)). However, the genetic...

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Detalles Bibliográficos
Autores principales:	Miotto, Paolo, Cabibbe, Andrea M., Feuerriegel, Silke, Casali, Nicola, Drobniewski, Francis, Rodionova, Yulia, Bakonyte, Daiva, Stakenas, Petras, Pimkina, Edita, Augustynowicz-Kopeć, Ewa, Degano, Massimo, Ambrosi, Alessandro, Hoffner, Sven, Mansjö, Mikael, Werngren, Jim, Rüsch-Gerdes, Sabine, Niemann, Stefan, Cirillo, Daniela M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212837/ https://www.ncbi.nlm.nih.gov/pubmed/25336456 http://dx.doi.org/10.1128/mBio.01819-14

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