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Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study
OBJECTIVE: To characterize the 90-day risk of hospitalization with pneumonia among patients treated with different anti-hypertensive drug classes. DESIGN: Population based cohort study using five linked databases. PARTICIPANTS: Individuals over the age of 65 who filled a new outpatient prescription...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212901/ https://www.ncbi.nlm.nih.gov/pubmed/25353172 http://dx.doi.org/10.1371/journal.pone.0110165 |
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author | Shah, Sachin McArthur, Eric Farag, Alexandra Nartey, Michael Fleet, Jamie L. Knoll, Greg A. Kim, S. Joseph Garg, Amit X. Jain, Arsh K. |
author_facet | Shah, Sachin McArthur, Eric Farag, Alexandra Nartey, Michael Fleet, Jamie L. Knoll, Greg A. Kim, S. Joseph Garg, Amit X. Jain, Arsh K. |
author_sort | Shah, Sachin |
collection | PubMed |
description | OBJECTIVE: To characterize the 90-day risk of hospitalization with pneumonia among patients treated with different anti-hypertensive drug classes. DESIGN: Population based cohort study using five linked databases. PARTICIPANTS: Individuals over the age of 65 who filled a new outpatient prescription for one of four anti-hypertensive medications: ACE inhibitors (n = 86 775), ARBs (n = 33 953), calcium channel blockers (CCB, n = 34 240), beta blockers (BB, n = 35 331) and thiazide diuretics (n = 64 186). PRIMARY OUTCOME: Hospitalization with pneumonia within 90 days of a qualifying prescription. We adjusted for ten a priori selected covariates, including age, sex, diabetes and number of visits to a family doctor. RESULTS: Baseline characteristics of the groups were relatively well matched, except for age, sex, diabetes and frequency of family doctor visits. 128 of the 86 775 patients (0.15%) initiated on an ACE inhibitor and 43 of the 33953 patients (0.13%) of patients initiated on an ARB were hospitalized with pneumonia in the subsequent 90 days. 135 of 64 186 patients (0.21%) initiated on a thiazide, 112 of 35 331 patients (.32%) initiated on a BB, and 89 of 34 240 (0.26%) patients initiated on a CCB achieved the primary outcome. Compared to calcium channel blockers, ACE inhibitors (adjusted OR 0.61, 95% CI 0.46 to 0.81) and ARBs (adjusted OR 0.52, 95% CI 0.36 to 0.76) were associated with a lower risk of pneumonia. No benefit was seen with thiazides (adjusted OR 0.87, 95% CI 0.66 to 1.14) or beta blockers (adjusted OR 1.21, 95% CI 0.91 to 1.60). CONCLUSION: Initiating medications that block the renin angiotensin system, compared to other anti-hypertensive medications, is associated with a small absolute reduction in the 90 day risk of hospitalization with pneumonia. |
format | Online Article Text |
id | pubmed-4212901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42129012014-11-05 Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study Shah, Sachin McArthur, Eric Farag, Alexandra Nartey, Michael Fleet, Jamie L. Knoll, Greg A. Kim, S. Joseph Garg, Amit X. Jain, Arsh K. PLoS One Research Article OBJECTIVE: To characterize the 90-day risk of hospitalization with pneumonia among patients treated with different anti-hypertensive drug classes. DESIGN: Population based cohort study using five linked databases. PARTICIPANTS: Individuals over the age of 65 who filled a new outpatient prescription for one of four anti-hypertensive medications: ACE inhibitors (n = 86 775), ARBs (n = 33 953), calcium channel blockers (CCB, n = 34 240), beta blockers (BB, n = 35 331) and thiazide diuretics (n = 64 186). PRIMARY OUTCOME: Hospitalization with pneumonia within 90 days of a qualifying prescription. We adjusted for ten a priori selected covariates, including age, sex, diabetes and number of visits to a family doctor. RESULTS: Baseline characteristics of the groups were relatively well matched, except for age, sex, diabetes and frequency of family doctor visits. 128 of the 86 775 patients (0.15%) initiated on an ACE inhibitor and 43 of the 33953 patients (0.13%) of patients initiated on an ARB were hospitalized with pneumonia in the subsequent 90 days. 135 of 64 186 patients (0.21%) initiated on a thiazide, 112 of 35 331 patients (.32%) initiated on a BB, and 89 of 34 240 (0.26%) patients initiated on a CCB achieved the primary outcome. Compared to calcium channel blockers, ACE inhibitors (adjusted OR 0.61, 95% CI 0.46 to 0.81) and ARBs (adjusted OR 0.52, 95% CI 0.36 to 0.76) were associated with a lower risk of pneumonia. No benefit was seen with thiazides (adjusted OR 0.87, 95% CI 0.66 to 1.14) or beta blockers (adjusted OR 1.21, 95% CI 0.91 to 1.60). CONCLUSION: Initiating medications that block the renin angiotensin system, compared to other anti-hypertensive medications, is associated with a small absolute reduction in the 90 day risk of hospitalization with pneumonia. Public Library of Science 2014-10-29 /pmc/articles/PMC4212901/ /pubmed/25353172 http://dx.doi.org/10.1371/journal.pone.0110165 Text en © 2014 Shah et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Shah, Sachin McArthur, Eric Farag, Alexandra Nartey, Michael Fleet, Jamie L. Knoll, Greg A. Kim, S. Joseph Garg, Amit X. Jain, Arsh K. Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title | Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title_full | Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title_fullStr | Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title_full_unstemmed | Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title_short | Risk of Hospitalization for Community Acquired Pneumonia with Renin-Angiotensin Blockade in Elderly Patients: A Population-Based Study |
title_sort | risk of hospitalization for community acquired pneumonia with renin-angiotensin blockade in elderly patients: a population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212901/ https://www.ncbi.nlm.nih.gov/pubmed/25353172 http://dx.doi.org/10.1371/journal.pone.0110165 |
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