A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion

Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing (99)Mo/(99m)Tc generators, intensifies the need for discovery of novel MPI agents i...

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Detalles Bibliográficos
Autores principales: Sharma, Vijay, Sivapackiam, Jothilingam, Harpstrite, Scott E., Prior, Julie L., Gu, Hannah, Rath, Nigam P., Piwnica-Worms, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212944/
https://www.ncbi.nlm.nih.gov/pubmed/25353349
http://dx.doi.org/10.1371/journal.pone.0109361
Descripción
Sumario:Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing (99)Mo/(99m)Tc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality (68)Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel (68)Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.

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