Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization

Microtubules are a highly validated target in cancer therapy. However, the clinical development of tubulin binding agents (TBA) has been hampered by toxicity and chemoresistance issues and has necessitated the search for new TBAs. Here, we report the identification of a novel cell permeable, tubulin...

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Detalles Bibliográficos
Autores principales: Choi, Bo-Hwa, Chattopadhaya, Souvik, Thanh, Le Nguyen, Feng, Lin, Nguyen, Quoc Toan, Lim, Chuan Bian, Harikishore, Amaravadhi, Nanga, Ravi Prakash Reddy, Bharatham, Nagakumar, Zhao, Yan, Liu, Xuewei, Yoon, Ho Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212991/
https://www.ncbi.nlm.nih.gov/pubmed/25354194
http://dx.doi.org/10.1371/journal.pone.0110955

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