Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial

We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individu...

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Detalles Bibliográficos
Autores principales: Mertens, Bart J. A., Jacobs, Wilco C. H., Brand, Ronald, Peul, Wilco C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213022/
https://www.ncbi.nlm.nih.gov/pubmed/25353633
http://dx.doi.org/10.1371/journal.pone.0111325
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author Mertens, Bart J. A.
Jacobs, Wilco C. H.
Brand, Ronald
Peul, Wilco C.
author_facet Mertens, Bart J. A.
Jacobs, Wilco C. H.
Brand, Ronald
Peul, Wilco C.
author_sort Mertens, Bart J. A.
collection PubMed
description We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individual patient level in a re-analysis of the wait-and-see group data. Both marginal structural model re-weighted estimates as well as propensity score adjusted analyses are presented. Results indicate that patients with high propensity to receive surgery may have beneficial effects at 2 years from delayed disc surgery.
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spelling pubmed-42130222014-11-05 Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial Mertens, Bart J. A. Jacobs, Wilco C. H. Brand, Ronald Peul, Wilco C. PLoS One Research Article We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individual patient level in a re-analysis of the wait-and-see group data. Both marginal structural model re-weighted estimates as well as propensity score adjusted analyses are presented. Results indicate that patients with high propensity to receive surgery may have beneficial effects at 2 years from delayed disc surgery. Public Library of Science 2014-10-29 /pmc/articles/PMC4213022/ /pubmed/25353633 http://dx.doi.org/10.1371/journal.pone.0111325 Text en © 2014 Mertens et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mertens, Bart J. A.
Jacobs, Wilco C. H.
Brand, Ronald
Peul, Wilco C.
Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title_full Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title_fullStr Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title_full_unstemmed Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title_short Assessment of Patient-Specific Surgery Effect Based on Weighted Estimation and Propensity Scoring in the Re-Analysis of the Sciatica Trial
title_sort assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213022/
https://www.ncbi.nlm.nih.gov/pubmed/25353633
http://dx.doi.org/10.1371/journal.pone.0111325
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