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Structural Basis of Substrate Selectivity of E. coli Prolidase

Prolidases, metalloproteases that catalyze the cleavage of Xaa-Pro dipeptides, are conserved enzymes found in prokaryotes and eukaryotes. In humans, prolidase is crucial for the recycling of collagen. To further characterize the essential elements of this enzyme, we utilized the Escherichia coli pro...

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Detalles Bibliográficos
Autores principales: Weaver, Jeremy, Watts, Tylan, Li, Pingwei, Rye, Hays S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213023/
https://www.ncbi.nlm.nih.gov/pubmed/25354344
http://dx.doi.org/10.1371/journal.pone.0111531