Sapropterin Dihydrochloride Mixed With Common Foods and Beverages

Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed i...

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Detalles Bibliográficos
Autores principales: Jurecki, Elaina R., Cunningham, Amy, Mahoney, John J., Tingley, Douglas, Chung, Stanley, James, Neil, Cohen-Pfeffer, Jessica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Phenylketonuria
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213132/
https://www.ncbi.nlm.nih.gov/pubmed/25382934
http://dx.doi.org/10.1097/TIN.0000000000000010
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author Jurecki, Elaina R.
Cunningham, Amy
Mahoney, John J.
Tingley, Douglas
Chung, Stanley
James, Neil
Cohen-Pfeffer, Jessica L.
author_facet Jurecki, Elaina R.
Cunningham, Amy
Mahoney, John J.
Tingley, Douglas
Chung, Stanley
James, Neil
Cohen-Pfeffer, Jessica L.
author_sort Jurecki, Elaina R.
collection PubMed
description Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information.
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spelling pubmed-42131322014-11-07 Sapropterin Dihydrochloride Mixed With Common Foods and Beverages Jurecki, Elaina R. Cunningham, Amy Mahoney, John J. Tingley, Douglas Chung, Stanley James, Neil Cohen-Pfeffer, Jessica L. Top Clin Nutr Phenylketonuria Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet. This study investigated the solubility and stability of sapropterin tablets and a sapropterin powder formulation when mixed in selected beverages and foods. Solubility was partial for the tablets and complete for the powder. The stability testing showed that 93% or more of active sapropterin dihydrochloride is present at 1 hour after either tablets or powders are mixed with certain foods and beverages. Mixing sapropterin powder with foods and beverages might facilitate its administration in patients who have difficulty swallowing the drug according to prescribing information. Lippincott Williams & Wilkins 2014-10 2014-11-11 /pmc/articles/PMC4213132/ /pubmed/25382934 http://dx.doi.org/10.1097/TIN.0000000000000010 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Phenylketonuria
Jurecki, Elaina R.
Cunningham, Amy
Mahoney, John J.
Tingley, Douglas
Chung, Stanley
James, Neil
Cohen-Pfeffer, Jessica L.
Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title_full Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title_fullStr Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title_full_unstemmed Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title_short Sapropterin Dihydrochloride Mixed With Common Foods and Beverages
title_sort sapropterin dihydrochloride mixed with common foods and beverages
topic Phenylketonuria
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213132/
https://www.ncbi.nlm.nih.gov/pubmed/25382934
http://dx.doi.org/10.1097/TIN.0000000000000010
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AT jamesneil sapropterindihydrochloridemixedwithcommonfoodsandbeverages
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