Cargando…
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six novel genome-wide significant associations, four in ITGAM-ITGAX, VAV3 a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213311/ https://www.ncbi.nlm.nih.gov/pubmed/25305756 http://dx.doi.org/10.1038/ng.3118 |
_version_ | 1782341805085294592 |
---|---|
author | Kiryluk, Krzysztof Li, Yifu Scolari, Francesco Sanna-Cherchi, Simone Choi, Murim Verbitsky, Miguel Fasel, David Lata, Sneh Prakash, Sindhuri Shapiro, Samantha Fischman, Clara Snyder, Holly J. Appel, Gerald Izzi, Claudia Viola, Battista Fabio Dallera, Nadia Vecchio, Lucia Del Barlassina, Cristina Salvi, Erika Bertinetto, Francesca Eleonora Amoroso, Antonio Savoldi, Silvana Rocchietti, Marcella Amore, Alessandro Peruzzi, Licia Coppo, Rosanna Salvadori, Maurizio Ravani, Pietro Magistroni, Riccardo Ghiggeri, Gian Marco Caridi, Gianluca Bodria, Monica Lugani, Francesca Allegri, Landino Delsante, Marco Maiorana, Mariarosa Magnano, Andrea Frasca, Giovanni Boer, Emanuela Boscutti, Giuliano Ponticelli, Claudio Mignani, Renzo Marcantoni, Carmelita Di Landro, Domenico Santoro, Domenico Pani, Antonello Polci, Rosaria Feriozzi, Sandro Chicca, Silvana Galliani, Marco Gigante, Maddalena Gesualdo, Loreto Zamboli, Pasquale Maixnerová, Dita Tesar, Vladimir Eitner, Frank Rauen, Thomas Floege, Jürgen Kovacs, Tibor Nagy, Judit Mucha, Krzysztof Pączek, Leszek Zaniew, Marcin Mizerska-Wasiak, Małgorzata Roszkowska-Blaim, Maria Pawlaczyk, Krzysztof Gale, Daniel Barratt, Jonathan Thibaudin, Lise Berthoux, Francois Canaud, Guillaume Boland, Anne Metzger, Marie Panzer, Ulf Suzuki, Hitoshi Goto, Shin Narita, Ichiei Caliskan, Yasar Xie, Jingyuan Hou, Ping Chen, Nan Zhang, Hong Wyatt, Robert J. Novak, Jan Julian, Bruce A. Feehally, John Stengel, Benedicte Cusi, Daniele Lifton, Richard P. Gharavi, Ali G. |
author_facet | Kiryluk, Krzysztof Li, Yifu Scolari, Francesco Sanna-Cherchi, Simone Choi, Murim Verbitsky, Miguel Fasel, David Lata, Sneh Prakash, Sindhuri Shapiro, Samantha Fischman, Clara Snyder, Holly J. Appel, Gerald Izzi, Claudia Viola, Battista Fabio Dallera, Nadia Vecchio, Lucia Del Barlassina, Cristina Salvi, Erika Bertinetto, Francesca Eleonora Amoroso, Antonio Savoldi, Silvana Rocchietti, Marcella Amore, Alessandro Peruzzi, Licia Coppo, Rosanna Salvadori, Maurizio Ravani, Pietro Magistroni, Riccardo Ghiggeri, Gian Marco Caridi, Gianluca Bodria, Monica Lugani, Francesca Allegri, Landino Delsante, Marco Maiorana, Mariarosa Magnano, Andrea Frasca, Giovanni Boer, Emanuela Boscutti, Giuliano Ponticelli, Claudio Mignani, Renzo Marcantoni, Carmelita Di Landro, Domenico Santoro, Domenico Pani, Antonello Polci, Rosaria Feriozzi, Sandro Chicca, Silvana Galliani, Marco Gigante, Maddalena Gesualdo, Loreto Zamboli, Pasquale Maixnerová, Dita Tesar, Vladimir Eitner, Frank Rauen, Thomas Floege, Jürgen Kovacs, Tibor Nagy, Judit Mucha, Krzysztof Pączek, Leszek Zaniew, Marcin Mizerska-Wasiak, Małgorzata Roszkowska-Blaim, Maria Pawlaczyk, Krzysztof Gale, Daniel Barratt, Jonathan Thibaudin, Lise Berthoux, Francois Canaud, Guillaume Boland, Anne Metzger, Marie Panzer, Ulf Suzuki, Hitoshi Goto, Shin Narita, Ichiei Caliskan, Yasar Xie, Jingyuan Hou, Ping Chen, Nan Zhang, Hong Wyatt, Robert J. Novak, Jan Julian, Bruce A. Feehally, John Stengel, Benedicte Cusi, Daniele Lifton, Richard P. Gharavi, Ali G. |
author_sort | Kiryluk, Krzysztof |
collection | PubMed |
description | We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six novel genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geo-spatial distribution of risk alleles is highly suggestive of multi-locus adaptation and the genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN. |
format | Online Article Text |
id | pubmed-4213311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42133112015-05-01 Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens Kiryluk, Krzysztof Li, Yifu Scolari, Francesco Sanna-Cherchi, Simone Choi, Murim Verbitsky, Miguel Fasel, David Lata, Sneh Prakash, Sindhuri Shapiro, Samantha Fischman, Clara Snyder, Holly J. Appel, Gerald Izzi, Claudia Viola, Battista Fabio Dallera, Nadia Vecchio, Lucia Del Barlassina, Cristina Salvi, Erika Bertinetto, Francesca Eleonora Amoroso, Antonio Savoldi, Silvana Rocchietti, Marcella Amore, Alessandro Peruzzi, Licia Coppo, Rosanna Salvadori, Maurizio Ravani, Pietro Magistroni, Riccardo Ghiggeri, Gian Marco Caridi, Gianluca Bodria, Monica Lugani, Francesca Allegri, Landino Delsante, Marco Maiorana, Mariarosa Magnano, Andrea Frasca, Giovanni Boer, Emanuela Boscutti, Giuliano Ponticelli, Claudio Mignani, Renzo Marcantoni, Carmelita Di Landro, Domenico Santoro, Domenico Pani, Antonello Polci, Rosaria Feriozzi, Sandro Chicca, Silvana Galliani, Marco Gigante, Maddalena Gesualdo, Loreto Zamboli, Pasquale Maixnerová, Dita Tesar, Vladimir Eitner, Frank Rauen, Thomas Floege, Jürgen Kovacs, Tibor Nagy, Judit Mucha, Krzysztof Pączek, Leszek Zaniew, Marcin Mizerska-Wasiak, Małgorzata Roszkowska-Blaim, Maria Pawlaczyk, Krzysztof Gale, Daniel Barratt, Jonathan Thibaudin, Lise Berthoux, Francois Canaud, Guillaume Boland, Anne Metzger, Marie Panzer, Ulf Suzuki, Hitoshi Goto, Shin Narita, Ichiei Caliskan, Yasar Xie, Jingyuan Hou, Ping Chen, Nan Zhang, Hong Wyatt, Robert J. Novak, Jan Julian, Bruce A. Feehally, John Stengel, Benedicte Cusi, Daniele Lifton, Richard P. Gharavi, Ali G. Nat Genet Article We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six novel genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geo-spatial distribution of risk alleles is highly suggestive of multi-locus adaptation and the genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN. 2014-10-12 2014-11 /pmc/articles/PMC4213311/ /pubmed/25305756 http://dx.doi.org/10.1038/ng.3118 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Kiryluk, Krzysztof Li, Yifu Scolari, Francesco Sanna-Cherchi, Simone Choi, Murim Verbitsky, Miguel Fasel, David Lata, Sneh Prakash, Sindhuri Shapiro, Samantha Fischman, Clara Snyder, Holly J. Appel, Gerald Izzi, Claudia Viola, Battista Fabio Dallera, Nadia Vecchio, Lucia Del Barlassina, Cristina Salvi, Erika Bertinetto, Francesca Eleonora Amoroso, Antonio Savoldi, Silvana Rocchietti, Marcella Amore, Alessandro Peruzzi, Licia Coppo, Rosanna Salvadori, Maurizio Ravani, Pietro Magistroni, Riccardo Ghiggeri, Gian Marco Caridi, Gianluca Bodria, Monica Lugani, Francesca Allegri, Landino Delsante, Marco Maiorana, Mariarosa Magnano, Andrea Frasca, Giovanni Boer, Emanuela Boscutti, Giuliano Ponticelli, Claudio Mignani, Renzo Marcantoni, Carmelita Di Landro, Domenico Santoro, Domenico Pani, Antonello Polci, Rosaria Feriozzi, Sandro Chicca, Silvana Galliani, Marco Gigante, Maddalena Gesualdo, Loreto Zamboli, Pasquale Maixnerová, Dita Tesar, Vladimir Eitner, Frank Rauen, Thomas Floege, Jürgen Kovacs, Tibor Nagy, Judit Mucha, Krzysztof Pączek, Leszek Zaniew, Marcin Mizerska-Wasiak, Małgorzata Roszkowska-Blaim, Maria Pawlaczyk, Krzysztof Gale, Daniel Barratt, Jonathan Thibaudin, Lise Berthoux, Francois Canaud, Guillaume Boland, Anne Metzger, Marie Panzer, Ulf Suzuki, Hitoshi Goto, Shin Narita, Ichiei Caliskan, Yasar Xie, Jingyuan Hou, Ping Chen, Nan Zhang, Hong Wyatt, Robert J. Novak, Jan Julian, Bruce A. Feehally, John Stengel, Benedicte Cusi, Daniele Lifton, Richard P. Gharavi, Ali G. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title_full | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title_fullStr | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title_full_unstemmed | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title_short | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens |
title_sort | discovery of new risk loci for iga nephropathy implicates genes involved in immunity against intestinal pathogens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213311/ https://www.ncbi.nlm.nih.gov/pubmed/25305756 http://dx.doi.org/10.1038/ng.3118 |
work_keys_str_mv | AT kirylukkrzysztof discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT liyifu discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT scolarifrancesco discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT sannacherchisimone discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT choimurim discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT verbitskymiguel discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT faseldavid discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT latasneh discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT prakashsindhuri discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT shapirosamantha discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT fischmanclara discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT snyderhollyj discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT appelgerald discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT izziclaudia discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT violabattistafabio discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT dalleranadia discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT vecchioluciadel discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT barlassinacristina discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT salvierika discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT bertinettofrancescaeleonora discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT amorosoantonio discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT savoldisilvana discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT rocchiettimarcella discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT amorealessandro discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT peruzzilicia discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT copporosanna discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT salvadorimaurizio discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT ravanipietro discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT magistroniriccardo discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT ghiggerigianmarco discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT caridigianluca discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT bodriamonica discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT luganifrancesca discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT allegrilandino discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT delsantemarco discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT maioranamariarosa discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT magnanoandrea discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT frascagiovanni discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT boeremanuela discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT boscuttigiuliano discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT ponticelliclaudio discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT mignanirenzo discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT marcantonicarmelita discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT dilandrodomenico discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT santorodomenico discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT paniantonello discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT polcirosaria discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT feriozzisandro discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT chiccasilvana discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT gallianimarco discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT gigantemaddalena discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT gesualdoloreto discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT zambolipasquale discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT maixnerovadita discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT tesarvladimir discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT eitnerfrank discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT rauenthomas discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT floegejurgen discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT kovacstibor discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT nagyjudit discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT muchakrzysztof discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT paczekleszek discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT zaniewmarcin discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT mizerskawasiakmałgorzata discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT roszkowskablaimmaria discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT pawlaczykkrzysztof discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT galedaniel discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT barrattjonathan discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT thibaudinlise discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT berthouxfrancois discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT canaudguillaume discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT bolandanne discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT metzgermarie discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT panzerulf discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT suzukihitoshi discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT gotoshin discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT naritaichiei discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT caliskanyasar discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT xiejingyuan discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT houping discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT chennan discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT zhanghong discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT wyattrobertj discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT novakjan discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT julianbrucea discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT feehallyjohn discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT stengelbenedicte discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT cusidaniele discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT liftonrichardp discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens AT gharavialig discoveryofnewrisklociforiganephropathyimplicatesgenesinvolvedinimmunityagainstintestinalpathogens |