Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

BACKGROUND: Bone metastases arise in nearly 70% of patients with advanced breast cancer, but the complex metastatic process has not been completely clarified yet. RANKL/RANK/OPG pathway modifications and the crosstalk between metastatic cells and bone have been indicated as potential drivers of the...

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Detalles Bibliográficos
Autores principales: Arrigoni, Chiara, De Luca, Paola, Gilardi, Mara, Previdi, Sara, Broggini, Massimo, Moretti, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213507/
https://www.ncbi.nlm.nih.gov/pubmed/25335447
http://dx.doi.org/10.1186/1476-4598-13-238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213507/
https://www.ncbi.nlm.nih.gov/pubmed/25335447
http://dx.doi.org/10.1186/1476-4598-13-238

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