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From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation
Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213562/ https://www.ncbi.nlm.nih.gov/pubmed/25296112 http://dx.doi.org/10.3390/v6103787 |
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author | Liu, Liang Cooper, Tamara Howley, Paul M. Hayball, John D. |
author_facet | Liu, Liang Cooper, Tamara Howley, Paul M. Hayball, John D. |
author_sort | Liu, Liang |
collection | PubMed |
description | Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and biogenesis of the virion membrane, the transformation from immature virion (IV) to mature virus (MV), and the role of several novel genes, which were previously uncharacterized, but have now been shown to be essential for VACV virion formation. This new knowledge will undoubtedly contribute to the rational design of safe, immunogenic vaccine candidates, or effective antivirals in the future. This review endeavors to provide an update on our current knowledge of the VACV maturation processes with a specific focus on the initiation of VACV replication through to the formation of mature virions. |
format | Online Article Text |
id | pubmed-4213562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42135622014-10-31 From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation Liu, Liang Cooper, Tamara Howley, Paul M. Hayball, John D. Viruses Review Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and biogenesis of the virion membrane, the transformation from immature virion (IV) to mature virus (MV), and the role of several novel genes, which were previously uncharacterized, but have now been shown to be essential for VACV virion formation. This new knowledge will undoubtedly contribute to the rational design of safe, immunogenic vaccine candidates, or effective antivirals in the future. This review endeavors to provide an update on our current knowledge of the VACV maturation processes with a specific focus on the initiation of VACV replication through to the formation of mature virions. MDPI 2014-10-07 /pmc/articles/PMC4213562/ /pubmed/25296112 http://dx.doi.org/10.3390/v6103787 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Liang Cooper, Tamara Howley, Paul M. Hayball, John D. From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title | From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title_full | From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title_fullStr | From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title_full_unstemmed | From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title_short | From Crescent to Mature Virion: Vaccinia Virus Assembly and Maturation |
title_sort | from crescent to mature virion: vaccinia virus assembly and maturation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213562/ https://www.ncbi.nlm.nih.gov/pubmed/25296112 http://dx.doi.org/10.3390/v6103787 |
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