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Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity

The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier d...

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Detalles Bibliográficos
Autores principales: Nunan, Robert, Harding, Keith G., Martin, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213725/
https://www.ncbi.nlm.nih.gov/pubmed/25359790
http://dx.doi.org/10.1242/dmm.016782
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author Nunan, Robert
Harding, Keith G.
Martin, Paul
author_facet Nunan, Robert
Harding, Keith G.
Martin, Paul
author_sort Nunan, Robert
collection PubMed
description The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier defect that has not healed in 3 months – has become a major therapeutic challenge throughout the Western world, and it is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. Despite being clinically and molecularly heterogeneous, all chronic wounds are generally assigned to one of three major clinical categories: leg ulcers, diabetic foot ulcers or pressure ulcers. Although we have gleaned much knowledge about the fundamental cellular and molecular mechanisms that underpin healthy, acute wound healing from various animal models, we have learned much less about chronic wound repair pathology from these models. This might largely be because the animal models being used in this field of research have failed to recapitulate the clinical features of chronic wounds. In this Clinical Puzzle article, we discuss the clinical complexity of chronic wounds and describe the best currently available models for investigating chronic wound pathology. We also assess how such models could be optimised to become more useful tools for uncovering pathological mechanisms and potential therapeutic treatments.
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spelling pubmed-42137252014-11-17 Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity Nunan, Robert Harding, Keith G. Martin, Paul Dis Model Mech Clinical Puzzle The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier defect that has not healed in 3 months – has become a major therapeutic challenge throughout the Western world, and it is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. Despite being clinically and molecularly heterogeneous, all chronic wounds are generally assigned to one of three major clinical categories: leg ulcers, diabetic foot ulcers or pressure ulcers. Although we have gleaned much knowledge about the fundamental cellular and molecular mechanisms that underpin healthy, acute wound healing from various animal models, we have learned much less about chronic wound repair pathology from these models. This might largely be because the animal models being used in this field of research have failed to recapitulate the clinical features of chronic wounds. In this Clinical Puzzle article, we discuss the clinical complexity of chronic wounds and describe the best currently available models for investigating chronic wound pathology. We also assess how such models could be optimised to become more useful tools for uncovering pathological mechanisms and potential therapeutic treatments. The Company of Biologists Limited 2014-11 /pmc/articles/PMC4213725/ /pubmed/25359790 http://dx.doi.org/10.1242/dmm.016782 Text en © 2014. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Clinical Puzzle
Nunan, Robert
Harding, Keith G.
Martin, Paul
Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title_full Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title_fullStr Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title_full_unstemmed Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title_short Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
title_sort clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
topic Clinical Puzzle
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213725/
https://www.ncbi.nlm.nih.gov/pubmed/25359790
http://dx.doi.org/10.1242/dmm.016782
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