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Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity
The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Limited
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213725/ https://www.ncbi.nlm.nih.gov/pubmed/25359790 http://dx.doi.org/10.1242/dmm.016782 |
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author | Nunan, Robert Harding, Keith G. Martin, Paul |
author_facet | Nunan, Robert Harding, Keith G. Martin, Paul |
author_sort | Nunan, Robert |
collection | PubMed |
description | The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier defect that has not healed in 3 months – has become a major therapeutic challenge throughout the Western world, and it is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. Despite being clinically and molecularly heterogeneous, all chronic wounds are generally assigned to one of three major clinical categories: leg ulcers, diabetic foot ulcers or pressure ulcers. Although we have gleaned much knowledge about the fundamental cellular and molecular mechanisms that underpin healthy, acute wound healing from various animal models, we have learned much less about chronic wound repair pathology from these models. This might largely be because the animal models being used in this field of research have failed to recapitulate the clinical features of chronic wounds. In this Clinical Puzzle article, we discuss the clinical complexity of chronic wounds and describe the best currently available models for investigating chronic wound pathology. We also assess how such models could be optimised to become more useful tools for uncovering pathological mechanisms and potential therapeutic treatments. |
format | Online Article Text |
id | pubmed-4213725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Company of Biologists Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-42137252014-11-17 Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity Nunan, Robert Harding, Keith G. Martin, Paul Dis Model Mech Clinical Puzzle The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier defect that has not healed in 3 months – has become a major therapeutic challenge throughout the Western world, and it is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. Despite being clinically and molecularly heterogeneous, all chronic wounds are generally assigned to one of three major clinical categories: leg ulcers, diabetic foot ulcers or pressure ulcers. Although we have gleaned much knowledge about the fundamental cellular and molecular mechanisms that underpin healthy, acute wound healing from various animal models, we have learned much less about chronic wound repair pathology from these models. This might largely be because the animal models being used in this field of research have failed to recapitulate the clinical features of chronic wounds. In this Clinical Puzzle article, we discuss the clinical complexity of chronic wounds and describe the best currently available models for investigating chronic wound pathology. We also assess how such models could be optimised to become more useful tools for uncovering pathological mechanisms and potential therapeutic treatments. The Company of Biologists Limited 2014-11 /pmc/articles/PMC4213725/ /pubmed/25359790 http://dx.doi.org/10.1242/dmm.016782 Text en © 2014. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Clinical Puzzle Nunan, Robert Harding, Keith G. Martin, Paul Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title | Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title_full | Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title_fullStr | Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title_full_unstemmed | Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title_short | Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
title_sort | clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity |
topic | Clinical Puzzle |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213725/ https://www.ncbi.nlm.nih.gov/pubmed/25359790 http://dx.doi.org/10.1242/dmm.016782 |
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