Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1

Alternative splicing of pre-mRNAs is an important mechanism that regulates cellular function in higher eukaryotes. A growing number of human genetic diseases involve splicing defects that are directly connected to their pathology. In myotonic dystrophy type 1 (DM1), several clinical manifestations h...

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Detalles Bibliográficos
Autores principales: García-Alcover, Irma, Colonques-Bellmunt, Jordi, Garijo, Raquel, Tormo, José R., Artero, Rubén, Álvarez-Abril, Mari Carmen, López Castel, Arturo, Pérez-Alonso, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213733/
https://www.ncbi.nlm.nih.gov/pubmed/25239918
http://dx.doi.org/10.1242/dmm.016592

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