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How Chromosome Mis-Segregation Leads to Cancer: Lessons from BubR1 Mouse Models
Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hallmark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecular me...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213761/ https://www.ncbi.nlm.nih.gov/pubmed/25256220 http://dx.doi.org/10.14348/molcells.2014.0233 |