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Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats

BACKGROUND: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. METHODS: In this study, we examined the effects of REKRG o...

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Autores principales: Park, Jung-Bum, Kwon, Sun Kwan, Nagar, Harsha, Jung, Saet-byel, Jeon, Byeong Hwa, Kim, Chang Sup, Oh, Jin-Hwan, Song, Hee-Jung, Kim, Cuk-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213846/
https://www.ncbi.nlm.nih.gov/pubmed/25379003
http://dx.doi.org/10.1016/j.jgr.2014.05.011
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author Park, Jung-Bum
Kwon, Sun Kwan
Nagar, Harsha
Jung, Saet-byel
Jeon, Byeong Hwa
Kim, Chang Sup
Oh, Jin-Hwan
Song, Hee-Jung
Kim, Cuk-Seong
author_facet Park, Jung-Bum
Kwon, Sun Kwan
Nagar, Harsha
Jung, Saet-byel
Jeon, Byeong Hwa
Kim, Chang Sup
Oh, Jin-Hwan
Song, Hee-Jung
Kim, Cuk-Seong
author_sort Park, Jung-Bum
collection PubMed
description BACKGROUND: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. METHODS: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats. RESULTS: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-α (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls. CONCLUSION: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.
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spelling pubmed-42138462014-11-06 Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats Park, Jung-Bum Kwon, Sun Kwan Nagar, Harsha Jung, Saet-byel Jeon, Byeong Hwa Kim, Chang Sup Oh, Jin-Hwan Song, Hee-Jung Kim, Cuk-Seong J Ginseng Res Research Article BACKGROUND: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. METHODS: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats. RESULTS: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-α (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls. CONCLUSION: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases. 2014-06-11 2014-10-15 /pmc/articles/PMC4213846/ /pubmed/25379003 http://dx.doi.org/10.1016/j.jgr.2014.05.011 Text en © 2014 The Korean Society of Ginseng. Published by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Research Article
Park, Jung-Bum
Kwon, Sun Kwan
Nagar, Harsha
Jung, Saet-byel
Jeon, Byeong Hwa
Kim, Chang Sup
Oh, Jin-Hwan
Song, Hee-Jung
Kim, Cuk-Seong
Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title_full Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title_fullStr Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title_full_unstemmed Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title_short Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
title_sort rg3-enriched korean red ginseng improves vascular function in spontaneously hypertensive rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213846/
https://www.ncbi.nlm.nih.gov/pubmed/25379003
http://dx.doi.org/10.1016/j.jgr.2014.05.011
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