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Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease

BACKGROUND: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). METHODS: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus...

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Autores principales: Bang, Chang Seok, Hong, So Hyung, Suk, Ki Tae, Kim, Jin Bong, Han, Sang Hak, Sung, Hotaik, Kim, Eun Ji, Kim, Myoung Jo, Kim, Moon Young, Baik, Soon Koo, Kim, Dong Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213850/
https://www.ncbi.nlm.nih.gov/pubmed/25378990
http://dx.doi.org/10.1016/j.jgr.2014.04.002
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author Bang, Chang Seok
Hong, So Hyung
Suk, Ki Tae
Kim, Jin Bong
Han, Sang Hak
Sung, Hotaik
Kim, Eun Ji
Kim, Myoung Jo
Kim, Moon Young
Baik, Soon Koo
Kim, Dong Joon
author_facet Bang, Chang Seok
Hong, So Hyung
Suk, Ki Tae
Kim, Jin Bong
Han, Sang Hak
Sung, Hotaik
Kim, Eun Ji
Kim, Myoung Jo
Kim, Moon Young
Baik, Soon Koo
Kim, Dong Joon
author_sort Bang, Chang Seok
collection PubMed
description BACKGROUND: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). METHODS: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a Lieber–DeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. RESULTS: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin-1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. CONCLUSION: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.
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spelling pubmed-42138502014-11-06 Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease Bang, Chang Seok Hong, So Hyung Suk, Ki Tae Kim, Jin Bong Han, Sang Hak Sung, Hotaik Kim, Eun Ji Kim, Myoung Jo Kim, Moon Young Baik, Soon Koo Kim, Dong Joon J Ginseng Res Research Article BACKGROUND: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). METHODS: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a Lieber–DeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. RESULTS: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37 ± 0.06 ng/mL, 0.39 ± 0.12 ng/mL, and 0.33 ± 0.07 ng/mL, respectively, vs. 0.88 ± 0.31 ng/mL; p < 0.05). Interleukin-1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. CONCLUSION: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments. 2014-04-25 2014-07 /pmc/articles/PMC4213850/ /pubmed/25378990 http://dx.doi.org/10.1016/j.jgr.2014.04.002 Text en © 2014 The Korean Society of Ginseng. Published by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Research Article
Bang, Chang Seok
Hong, So Hyung
Suk, Ki Tae
Kim, Jin Bong
Han, Sang Hak
Sung, Hotaik
Kim, Eun Ji
Kim, Myoung Jo
Kim, Moon Young
Baik, Soon Koo
Kim, Dong Joon
Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title_full Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title_fullStr Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title_full_unstemmed Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title_short Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut–liver axis of alcoholic liver disease
title_sort effects of korean red ginseng (panax ginseng), urushiol (rhus vernicifera stokes), and probiotics (lactobacillus rhamnosus r0011 and lactobacillus acidophilus r0052) on the gut–liver axis of alcoholic liver disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213850/
https://www.ncbi.nlm.nih.gov/pubmed/25378990
http://dx.doi.org/10.1016/j.jgr.2014.04.002
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