Cargando…

Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3

BACKGROUND: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Jae-Hyoung, Choi, Hwa-Jung, Song, Hyuk-Hwan, Hong, Eun-Hye, Lee, Bo-Ra, Oh, Sei-Ryang, Choi, Kwangman, Yeo, Sang-Gu, Lee, Yong-Pyo, Cho, Sungchan, Ko, Hyun-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213867/
https://www.ncbi.nlm.nih.gov/pubmed/25378991
http://dx.doi.org/10.1016/j.jgr.2014.04.003
_version_ 1782341879609688064
author Song, Jae-Hyoung
Choi, Hwa-Jung
Song, Hyuk-Hwan
Hong, Eun-Hye
Lee, Bo-Ra
Oh, Sei-Ryang
Choi, Kwangman
Yeo, Sang-Gu
Lee, Yong-Pyo
Cho, Sungchan
Ko, Hyun-Jeong
author_facet Song, Jae-Hyoung
Choi, Hwa-Jung
Song, Hyuk-Hwan
Hong, Eun-Hye
Lee, Bo-Ra
Oh, Sei-Ryang
Choi, Kwangman
Yeo, Sang-Gu
Lee, Yong-Pyo
Cho, Sungchan
Ko, Hyun-Jeong
author_sort Song, Jae-Hyoung
collection PubMed
description BACKGROUND: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), and human rhinovirus 3 (HRV3). METHODS: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay. RESULTS: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of 100 μg/mL. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at 100 μg/mL. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug. CONCLUSION: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection.
format Online
Article
Text
id pubmed-4213867
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-42138672014-11-06 Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3 Song, Jae-Hyoung Choi, Hwa-Jung Song, Hyuk-Hwan Hong, Eun-Hye Lee, Bo-Ra Oh, Sei-Ryang Choi, Kwangman Yeo, Sang-Gu Lee, Yong-Pyo Cho, Sungchan Ko, Hyun-Jeong J Ginseng Res Research Article BACKGROUND: Ginsenosides are the major components responsible for the biochemical and pharmacological actions of ginseng, and have been shown to have various biological activities. In this study, we investigated the antiviral activities of seven ginsenosides [protopanaxatriol (PT) type: Re, Rf, and Rg2; protopanaxadiol (PD) type: Rb1, Rb2, Rc, and Rd)] against coxsackievirus B3 (CVB3), enterovirus 71 (EV71), and human rhinovirus 3 (HRV3). METHODS: Assays of antiviral activity and cytotoxicity were evaluated by the sulforhodamine B method using the cytopathic effect (CPE) reduction assay. RESULTS: The antiviral assays demonstrated that, of the seven ginsenosides, the PT-type ginsenosides (Re, Rf, and Rg2) possess significant antiviral activities against CVB3 and HRV3 at a concentration of 100 μg/mL. Among the PT-type ginsenosides, only ginsenoside Rg2 showed significant anti-EV71 activity with no cytotoxicity to cells at 100 μg/mL. The PD-type ginsenosides (Rb1, Rb2, Rc, and Rd), by contrast, did not show any significant antiviral activity against CVB3, EV71, and HRV3, and exhibited cytotoxic effects to virus-infected cells. Notably, the antiviral efficacies of PT-type ginsenosides were comparable to those of ribavirin, a commonly used antiviral drug. CONCLUSION: Collectively, our findings suggest that the ginsenosides Re, Rf, and Rg2 have the potential to be effective in the treatment of CVB3, EV71, and HRV3 infection. 2014-04-29 2014-07 /pmc/articles/PMC4213867/ /pubmed/25378991 http://dx.doi.org/10.1016/j.jgr.2014.04.003 Text en © 2014 The Korean Society of Ginseng. Published by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Research Article
Song, Jae-Hyoung
Choi, Hwa-Jung
Song, Hyuk-Hwan
Hong, Eun-Hye
Lee, Bo-Ra
Oh, Sei-Ryang
Choi, Kwangman
Yeo, Sang-Gu
Lee, Yong-Pyo
Cho, Sungchan
Ko, Hyun-Jeong
Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title_full Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title_fullStr Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title_full_unstemmed Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title_short Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3
title_sort antiviral activity of ginsenosides against coxsackievirus b3, enterovirus 71, and human rhinovirus 3
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213867/
https://www.ncbi.nlm.nih.gov/pubmed/25378991
http://dx.doi.org/10.1016/j.jgr.2014.04.003
work_keys_str_mv AT songjaehyoung antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT choihwajung antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT songhyukhwan antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT hongeunhye antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT leebora antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT ohseiryang antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT choikwangman antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT yeosanggu antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT leeyongpyo antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT chosungchan antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3
AT kohyunjeong antiviralactivityofginsenosidesagainstcoxsackievirusb3enterovirus71andhumanrhinovirus3