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Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity
BACKGROUND: Tuberculosis is a leading cause of death in the world. A new alternative for the treatment of tuberculosis is urgently required, due to the emergence of multidrug resistant Mycobacterium tuberculosis. AIM: There is currently considerable interest in developing potential drugs from medici...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213978/ https://www.ncbi.nlm.nih.gov/pubmed/25364208 http://dx.doi.org/10.4103/0974-8520.141952 |
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author | Kumar, J. Komal Devi Prasad, A. G. Chaturvedi, Vinita |
author_facet | Kumar, J. Komal Devi Prasad, A. G. Chaturvedi, Vinita |
author_sort | Kumar, J. Komal |
collection | PubMed |
description | BACKGROUND: Tuberculosis is a leading cause of death in the world. A new alternative for the treatment of tuberculosis is urgently required, due to the emergence of multidrug resistant Mycobacterium tuberculosis. AIM: There is currently considerable interest in developing potential drugs from medicinal plants for treating tuberculosis. To evaluate anti-tubercular activity in the leaves of Kingiodendron pinnatum Rox. Hams., Humboldtia brunonis Wall., Indigofera cassioides Rottl.ex DC., Derris scandens Benth. and Ceasalpinia mimosoides Lamk. MATERIALS AND METHODS: Non-polar and polar solvent extracts of leaves of these medicinal legumes were tested against M. tuberculosis H37RV and minimum inhibitory concentrations (MICs) were determined by the agar based proportion assay. RESULTS: Phytochemical screening for secondary metabolites revealed the presence of saponins, steroids, anthro-quinones, terpinods, flavonoids and phlabotanins. Crude leaf extracts of these plants have shown MIC value of 50 μg/ml as against the standard drug Isoniazid value of 0.025 μg/ml. CONCLUSION: Results showed that crude extracts of legume leaves screened exhibited potential anti-tubercular activity against M. tuberculosis and further work is required to identify the active molecule of these legumes, to get a novel anti-tubercular drug. This is the maiden finding on anti-tubercular activity of these medicinal legumes. |
format | Online Article Text |
id | pubmed-4213978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42139782014-10-31 Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity Kumar, J. Komal Devi Prasad, A. G. Chaturvedi, Vinita Ayu Pharmacological Study BACKGROUND: Tuberculosis is a leading cause of death in the world. A new alternative for the treatment of tuberculosis is urgently required, due to the emergence of multidrug resistant Mycobacterium tuberculosis. AIM: There is currently considerable interest in developing potential drugs from medicinal plants for treating tuberculosis. To evaluate anti-tubercular activity in the leaves of Kingiodendron pinnatum Rox. Hams., Humboldtia brunonis Wall., Indigofera cassioides Rottl.ex DC., Derris scandens Benth. and Ceasalpinia mimosoides Lamk. MATERIALS AND METHODS: Non-polar and polar solvent extracts of leaves of these medicinal legumes were tested against M. tuberculosis H37RV and minimum inhibitory concentrations (MICs) were determined by the agar based proportion assay. RESULTS: Phytochemical screening for secondary metabolites revealed the presence of saponins, steroids, anthro-quinones, terpinods, flavonoids and phlabotanins. Crude leaf extracts of these plants have shown MIC value of 50 μg/ml as against the standard drug Isoniazid value of 0.025 μg/ml. CONCLUSION: Results showed that crude extracts of legume leaves screened exhibited potential anti-tubercular activity against M. tuberculosis and further work is required to identify the active molecule of these legumes, to get a novel anti-tubercular drug. This is the maiden finding on anti-tubercular activity of these medicinal legumes. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4213978/ /pubmed/25364208 http://dx.doi.org/10.4103/0974-8520.141952 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pharmacological Study Kumar, J. Komal Devi Prasad, A. G. Chaturvedi, Vinita Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title | Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title_full | Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title_fullStr | Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title_full_unstemmed | Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title_short | Phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
title_sort | phytochemical screening of five medicinal legumes and their evaluation for in vitro anti-tubercular activity |
topic | Pharmacological Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213978/ https://www.ncbi.nlm.nih.gov/pubmed/25364208 http://dx.doi.org/10.4103/0974-8520.141952 |
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