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Role of DNA methylation and the DNA methyltransferases in learning and memory

Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methyl...

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Detalles Bibliográficos
Autores principales: Morris, Michael J., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214178/
https://www.ncbi.nlm.nih.gov/pubmed/25364286
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author Morris, Michael J.
Monteggia, Lisa M.
author_facet Morris, Michael J.
Monteggia, Lisa M.
author_sort Morris, Michael J.
collection PubMed
description Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methylation and demethylation of specific genes in the brain may play a fundamental role in learning, memory formation, and behavioral plasticity. The current review focuses on the emergence of data that support the role of DNA methylation and demethylation, and its molecular mediators in memory formation.
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spelling pubmed-42141782014-10-31 Role of DNA methylation and the DNA methyltransferases in learning and memory Morris, Michael J. Monteggia, Lisa M. Dialogues Clin Neurosci Translational Research Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methylation and demethylation of specific genes in the brain may play a fundamental role in learning, memory formation, and behavioral plasticity. The current review focuses on the emergence of data that support the role of DNA methylation and demethylation, and its molecular mediators in memory formation. Les Laboratoires Servier 2014-09 /pmc/articles/PMC4214178/ /pubmed/25364286 Text en Copyright: © 2014 Institut la Conférence Hippocrate - Servier Research Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Morris, Michael J.
Monteggia, Lisa M.
Role of DNA methylation and the DNA methyltransferases in learning and memory
title Role of DNA methylation and the DNA methyltransferases in learning and memory
title_full Role of DNA methylation and the DNA methyltransferases in learning and memory
title_fullStr Role of DNA methylation and the DNA methyltransferases in learning and memory
title_full_unstemmed Role of DNA methylation and the DNA methyltransferases in learning and memory
title_short Role of DNA methylation and the DNA methyltransferases in learning and memory
title_sort role of dna methylation and the dna methyltransferases in learning and memory
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214178/
https://www.ncbi.nlm.nih.gov/pubmed/25364286
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