A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

We previously reported high expression of RAD51 and increased homologous recombination (HR) rates in multiple myeloma (MM) cells, and showed that genomic instability and disease progression are commensurate with HR levels. Moreover, high RAD51 expression in vivo is associated with chemoresistance an...

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Detalles Bibliográficos
Autores principales: Alagpulinsa, David A., Ayyadevara, Srinivas, Shmookler Reis, Robert Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214226/
https://www.ncbi.nlm.nih.gov/pubmed/25401086
http://dx.doi.org/10.3389/fonc.2014.00289

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