Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications

Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mech...

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Detalles Bibliográficos
Autores principales: Imashimizu, Masahiko, Shimamoto, Nobuo, Oshima, Taku, Kashlev, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214235/
https://www.ncbi.nlm.nih.gov/pubmed/25764114
http://dx.doi.org/10.4161/trns.28285
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author Imashimizu, Masahiko
Shimamoto, Nobuo
Oshima, Taku
Kashlev, Mikhail
author_facet Imashimizu, Masahiko
Shimamoto, Nobuo
Oshima, Taku
Kashlev, Mikhail
author_sort Imashimizu, Masahiko
collection PubMed
description Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mechanism of regulation, we introduce the concept of heterogeneity into the previously proposed alternative models of elongation, power stroke and Brownian ratchet. We also discuss molecular origins and physiological significances of the heterogeneity.
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spelling pubmed-42142352015-09-27 Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications Imashimizu, Masahiko Shimamoto, Nobuo Oshima, Taku Kashlev, Mikhail Transcription Review Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mechanism of regulation, we introduce the concept of heterogeneity into the previously proposed alternative models of elongation, power stroke and Brownian ratchet. We also discuss molecular origins and physiological significances of the heterogeneity. Landes Bioscience 2014-02-21 /pmc/articles/PMC4214235/ /pubmed/25764114 http://dx.doi.org/10.4161/trns.28285 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Imashimizu, Masahiko
Shimamoto, Nobuo
Oshima, Taku
Kashlev, Mikhail
Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title_full Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title_fullStr Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title_full_unstemmed Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title_short Transcription elongation: Heterogeneous tracking of RNA polymerase and its biological implications
title_sort transcription elongation: heterogeneous tracking of rna polymerase and its biological implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214235/
https://www.ncbi.nlm.nih.gov/pubmed/25764114
http://dx.doi.org/10.4161/trns.28285
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