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mTOR pathway: A current, up-to-date mini-review (Review)
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that was initially identified as the cellular target of rapamycin. This kinase regulates cell growth, proliferation, motility and survival, as well as the gene transcription and protein synthesis that are activated in response...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214394/ https://www.ncbi.nlm.nih.gov/pubmed/25360163 http://dx.doi.org/10.3892/ol.2014.2608 |
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author | ZAROGOULIDIS, PAUL LAMPAKI, SOFIA TURNER, J. FRANCIS HUANG, HAIDONG KAKOLYRIS, STYLIANOS SYRIGOS, KONSTANTINOS ZAROGOULIDIS, KONSTANTINOS |
author_facet | ZAROGOULIDIS, PAUL LAMPAKI, SOFIA TURNER, J. FRANCIS HUANG, HAIDONG KAKOLYRIS, STYLIANOS SYRIGOS, KONSTANTINOS ZAROGOULIDIS, KONSTANTINOS |
author_sort | ZAROGOULIDIS, PAUL |
collection | PubMed |
description | Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that was initially identified as the cellular target of rapamycin. This kinase regulates cell growth, proliferation, motility and survival, as well as the gene transcription and protein synthesis that are activated in response to hormones, growth factors and nutrients. Results from preclinical studies have indicated that factors antagonizing the mTOR pathway exert an antitumor effect on lung cancer. Furthermore, primary clinical trials of mTOR inhibitors have demonstrated that the inhibitors may be effective against lung carcinoma. The present study explores the association between mTOR and lung carcinogenesis and describes the clinical trials of mTOR inhibitors. |
format | Online Article Text |
id | pubmed-4214394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-42143942014-10-30 mTOR pathway: A current, up-to-date mini-review (Review) ZAROGOULIDIS, PAUL LAMPAKI, SOFIA TURNER, J. FRANCIS HUANG, HAIDONG KAKOLYRIS, STYLIANOS SYRIGOS, KONSTANTINOS ZAROGOULIDIS, KONSTANTINOS Oncol Lett Articles Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that was initially identified as the cellular target of rapamycin. This kinase regulates cell growth, proliferation, motility and survival, as well as the gene transcription and protein synthesis that are activated in response to hormones, growth factors and nutrients. Results from preclinical studies have indicated that factors antagonizing the mTOR pathway exert an antitumor effect on lung cancer. Furthermore, primary clinical trials of mTOR inhibitors have demonstrated that the inhibitors may be effective against lung carcinoma. The present study explores the association between mTOR and lung carcinogenesis and describes the clinical trials of mTOR inhibitors. D.A. Spandidos 2014-12 2014-10-10 /pmc/articles/PMC4214394/ /pubmed/25360163 http://dx.doi.org/10.3892/ol.2014.2608 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ZAROGOULIDIS, PAUL LAMPAKI, SOFIA TURNER, J. FRANCIS HUANG, HAIDONG KAKOLYRIS, STYLIANOS SYRIGOS, KONSTANTINOS ZAROGOULIDIS, KONSTANTINOS mTOR pathway: A current, up-to-date mini-review (Review) |
title | mTOR pathway: A current, up-to-date mini-review (Review) |
title_full | mTOR pathway: A current, up-to-date mini-review (Review) |
title_fullStr | mTOR pathway: A current, up-to-date mini-review (Review) |
title_full_unstemmed | mTOR pathway: A current, up-to-date mini-review (Review) |
title_short | mTOR pathway: A current, up-to-date mini-review (Review) |
title_sort | mtor pathway: a current, up-to-date mini-review (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214394/ https://www.ncbi.nlm.nih.gov/pubmed/25360163 http://dx.doi.org/10.3892/ol.2014.2608 |
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