Cargando…
Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer
A 64-year-old woman presented with dizziness, after two weeks of experiencing symptoms. Chest computed tomography revealed a peripheral nodule in her left upper lobe, and brain magnetic resonance imaging (MRI) demonstrated the presence of multiple brain masses. The patient underwent whole-brain radi...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214432/ https://www.ncbi.nlm.nih.gov/pubmed/25364413 http://dx.doi.org/10.3892/ol.2014.2603 |
_version_ | 1782341956748181504 |
---|---|
author | ODA, NAOHIRO SAKUGAWA, MAKOTO BESSHO, AKIHIRO HORIUCHI, TAKESHI HOSOKAWA, SHINOBU TOYOTA, YOSUKE FUKAMATSU, NOBUAKI NISHII, KAZUYA WATANABE, YOICHI |
author_facet | ODA, NAOHIRO SAKUGAWA, MAKOTO BESSHO, AKIHIRO HORIUCHI, TAKESHI HOSOKAWA, SHINOBU TOYOTA, YOSUKE FUKAMATSU, NOBUAKI NISHII, KAZUYA WATANABE, YOICHI |
author_sort | ODA, NAOHIRO |
collection | PubMed |
description | A 64-year-old woman presented with dizziness, after two weeks of experiencing symptoms. Chest computed tomography revealed a peripheral nodule in her left upper lobe, and brain magnetic resonance imaging (MRI) demonstrated the presence of multiple brain masses. The patient underwent whole-brain radiotherapy based on a tentative diagnosis of lung cancer with multiple brain metastases. The diagnosis was confirmed by endobronchial biopsy as T4N3M1b, stage IV lung adenocarcinoma with an epidermal growth factor receptor mutation. On the 31st day of hospitalization, the patient developed severe headache. Subsequent magnetic resonance venography revealed defects in the superior sagittal, right sigmoid, and right transverse venous sinuses and the right internal jugular vein. Anticoagulation therapy with unfractionated heparin and warfarin was immediately administered following diagnosis of cerebral venous sinus thrombosis (CVST). Brain MRI demonstrated leptomeningeal gadolinium enhancement in front of the pons and medulla. Positive cerebrospinal fluid tumor cytology confirmed the diagnosis of leptomeningeal carcinomatosis. Following four weeks of antithrombotic therapy, complete thrombolysis was confirmed by magnetic resonance venography. Effective treatment with gefitinib was administered, and the patient survived for 10 months after the diagnosis of CVST and leptomeningeal carcinomatosis. Adequate early diagnosis and treatment of CVST enabled an excellent survival rate for the patient, despite leptomeningeal carcinomatosis. Following the development of headaches in patients with lung cancer, CVST, although rare, should be considered. Furthermore, following a diagnosis of CVST, leptomeningeal carcinomatosis should be investigated as an underlying cause. |
format | Online Article Text |
id | pubmed-4214432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-42144322014-10-31 Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer ODA, NAOHIRO SAKUGAWA, MAKOTO BESSHO, AKIHIRO HORIUCHI, TAKESHI HOSOKAWA, SHINOBU TOYOTA, YOSUKE FUKAMATSU, NOBUAKI NISHII, KAZUYA WATANABE, YOICHI Oncol Lett Articles A 64-year-old woman presented with dizziness, after two weeks of experiencing symptoms. Chest computed tomography revealed a peripheral nodule in her left upper lobe, and brain magnetic resonance imaging (MRI) demonstrated the presence of multiple brain masses. The patient underwent whole-brain radiotherapy based on a tentative diagnosis of lung cancer with multiple brain metastases. The diagnosis was confirmed by endobronchial biopsy as T4N3M1b, stage IV lung adenocarcinoma with an epidermal growth factor receptor mutation. On the 31st day of hospitalization, the patient developed severe headache. Subsequent magnetic resonance venography revealed defects in the superior sagittal, right sigmoid, and right transverse venous sinuses and the right internal jugular vein. Anticoagulation therapy with unfractionated heparin and warfarin was immediately administered following diagnosis of cerebral venous sinus thrombosis (CVST). Brain MRI demonstrated leptomeningeal gadolinium enhancement in front of the pons and medulla. Positive cerebrospinal fluid tumor cytology confirmed the diagnosis of leptomeningeal carcinomatosis. Following four weeks of antithrombotic therapy, complete thrombolysis was confirmed by magnetic resonance venography. Effective treatment with gefitinib was administered, and the patient survived for 10 months after the diagnosis of CVST and leptomeningeal carcinomatosis. Adequate early diagnosis and treatment of CVST enabled an excellent survival rate for the patient, despite leptomeningeal carcinomatosis. Following the development of headaches in patients with lung cancer, CVST, although rare, should be considered. Furthermore, following a diagnosis of CVST, leptomeningeal carcinomatosis should be investigated as an underlying cause. D.A. Spandidos 2014-12 2014-10-10 /pmc/articles/PMC4214432/ /pubmed/25364413 http://dx.doi.org/10.3892/ol.2014.2603 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ODA, NAOHIRO SAKUGAWA, MAKOTO BESSHO, AKIHIRO HORIUCHI, TAKESHI HOSOKAWA, SHINOBU TOYOTA, YOSUKE FUKAMATSU, NOBUAKI NISHII, KAZUYA WATANABE, YOICHI Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title | Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title_full | Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title_fullStr | Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title_full_unstemmed | Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title_short | Cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
title_sort | cerebral venous sinus thrombosis concomitant with leptomeningeal carcinomatosis, in a patient with epidermal growth factor receptor-mutated lung cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214432/ https://www.ncbi.nlm.nih.gov/pubmed/25364413 http://dx.doi.org/10.3892/ol.2014.2603 |
work_keys_str_mv | AT odanaohiro cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT sakugawamakoto cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT besshoakihiro cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT horiuchitakeshi cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT hosokawashinobu cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT toyotayosuke cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT fukamatsunobuaki cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT nishiikazuya cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer AT watanabeyoichi cerebralvenoussinusthrombosisconcomitantwithleptomeningealcarcinomatosisinapatientwithepidermalgrowthfactorreceptormutatedlungcancer |