Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framework that integr...

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Detalles Bibliográficos
Autores principales: Kichaev, Gleb, Yang, Wen-Yun, Lindstrom, Sara, Hormozdiari, Farhad, Eskin, Eleazar, Price, Alkes L., Kraft, Peter, Pasaniuc, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214605/
https://www.ncbi.nlm.nih.gov/pubmed/25357204
http://dx.doi.org/10.1371/journal.pgen.1004722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214605/
https://www.ncbi.nlm.nih.gov/pubmed/25357204
http://dx.doi.org/10.1371/journal.pgen.1004722

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