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Onward from the cradle

This essay records a voyage of discovery from the “cradle of cell biology” to the present, focused on the biology of the oldest known cell organelle, the cilium. In the “romper room” of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born. From the “summer of lo...

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Detalles Bibliográficos
Autor principal: Satir, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214774/
https://www.ncbi.nlm.nih.gov/pubmed/25360050
http://dx.doi.org/10.1091/mbc.E14-05-1014
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author Satir, Peter
author_facet Satir, Peter
author_sort Satir, Peter
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description This essay records a voyage of discovery from the “cradle of cell biology” to the present, focused on the biology of the oldest known cell organelle, the cilium. In the “romper room” of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born. From the “summer of love,” students and colleagues joined the journey to test switch-point mechanisms of motility. In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecules cross ciliary necklace barriers for cell signaling.
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spelling pubmed-42147742015-01-16 Onward from the cradle Satir, Peter Mol Biol Cell ASCB Award Essays This essay records a voyage of discovery from the “cradle of cell biology” to the present, focused on the biology of the oldest known cell organelle, the cilium. In the “romper room” of cilia and microtubule (MT) biology, the sliding MT hypothesis of ciliary motility was born. From the “summer of love,” students and colleagues joined the journey to test switch-point mechanisms of motility. In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindled, leading to discoveries relating ciliogenesis to autophagy and hypotheses of how molecules cross ciliary necklace barriers for cell signaling. The American Society for Cell Biology 2014-11-01 /pmc/articles/PMC4214774/ /pubmed/25360050 http://dx.doi.org/10.1091/mbc.E14-05-1014 Text en © 2014 Satir. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle ASCB Award Essays
Satir, Peter
Onward from the cradle
title Onward from the cradle
title_full Onward from the cradle
title_fullStr Onward from the cradle
title_full_unstemmed Onward from the cradle
title_short Onward from the cradle
title_sort onward from the cradle
topic ASCB Award Essays
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214774/
https://www.ncbi.nlm.nih.gov/pubmed/25360050
http://dx.doi.org/10.1091/mbc.E14-05-1014
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