Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production

Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immunometabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysacc...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Liu, Ting-yu, Lai, Chun-Hsiang, Rao, Yan-hua, Choi, Moon-Chang, Chi, Jen-Tsan, Dai, Jian-wu, Rathmell, Jeffrey C., Yao, Tso-Pang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214777/
https://www.ncbi.nlm.nih.gov/pubmed/25187650
http://dx.doi.org/10.1091/mbc.E13-12-0757

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