Cargando…

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling through its activity in the destruction complex with Axin, GSK3β, and CK1 that targets β-catenin/Armadillo (β-cat/Arm) for proteosomal degradation. The destruction complex forms macromolecular p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kunttas-Tatli, Ezgi, Roberts, David M., McCartney, Brooke M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214788/ https://www.ncbi.nlm.nih.gov/pubmed/25208568 http://dx.doi.org/10.1091/mbc.E14-04-0885

Ejemplares similares

The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling
por: Kunttas-Tatli, Ezgi, et al.
Publicado: (2015)

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
por: Roberts, David M., et al.
Publicado: (2011)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

APC Moonlights to Prevent Wnt Signalosome Assembly
por: McGough, Ian John, et al.
Publicado: (2018)

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
por: Nilsson, Jakob, et al.
Publicado: (2008)

Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis
por: McCartney, Brooke M., et al.
Publicado: (1999)

Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly
por: Kang, Kexin, et al.
Publicado: (2022)

Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity
por: Pattison, Amanda M., et al.
Publicado: (2020)

Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
por: Barua, Dipak, et al.
Publicado: (2013)

Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo
por: Schaefer, Kristina N., et al.
Publicado: (2018)

The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
por: Miyakawa, Kei, et al.
Publicado: (2017)

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
por: Cai, Jing, et al.
Publicado: (2015)

Wnt signaling and colon carcinogenesis: Beyond APC
por: Najdi, Rani, et al.
Publicado: (2011)

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response
por: Stefanski, Casey D., et al.
Publicado: (2020)

The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
por: Liu, Xiaolei, et al.
Publicado: (2023)

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
por: Pronobis, Mira I, et al.
Publicado: (2015)

Intracellular shuttling of a Drosophila APC tumour suppressor homolog
por: Cliffe, Adam, et al.
Publicado: (2004)

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
por: Ranes, Michael, et al.
Publicado: (2021)

APC(CDH1) Targets MgcRacGAP for Destruction in the Late M Phase
por: Nishimura, Koutarou, et al.
Publicado: (2013)

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing
por: Tian, Ai, et al.
Publicado: (2017)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1
por: van Leuken, Renske, et al.
Publicado: (2009)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β
por: Bakshi, Siddharth, et al.
Publicado: (2017)

Correction: APC(CDH1) Targets MgcRacGAP for Destruction in the Late M Phase
Publicado: (2014)

APC sets the Wnt tone necessary for cerebral cortical progenitor development
por: Nakagawa, Naoki, et al.
Publicado: (2017)

Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint
por: Wild, Thomas, et al.
Publicado: (2018)

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation
por: Yatskevich, Stanislau, et al.
Publicado: (2021)

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis
por: Bellis, Julien, et al.
Publicado: (2012)

Frequent Alteration of the Tumor Suppressor Gene APC in Sporadic Canine Colorectal Tumors
por: Youmans, Lydia, et al.
Publicado: (2012)

Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
por: May, Karen M., et al.
Publicado: (2017)

Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
por: Roberts, David M., et al.
Publicado: (2012)

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
por: Zhang, Suyang, et al.
Publicado: (2019)

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
por: Lee, Ethan, et al.
Publicado: (2003)

Thymoquinone attenuates tumor growth in Apc(Min) mice by interference with Wnt-signaling
por: Lang, Michaela, et al.
Publicado: (2013)

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression
por: Mohamed, Noha-Ehssan, et al.
Publicado: (2019)

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer
por: Kang, Hee Eun, et al.
Publicado: (2021)

Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites
por: Weiner, Alexis T., et al.
Publicado: (2018)

CBX2 is required to stabilize the testis pathway by repressing Wnt signaling
por: Garcia-Moreno, S. Alexandra, et al.
Publicado: (2019)

Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics
por: Mukherjee, Abhirup, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t328jnl423i3v167htgcfvrg07