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Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling through its activity in the destruction complex with Axin, GSK3β, and CK1 that targets β-catenin/Armadillo (β-cat/Arm) for proteosomal degradation. The destruction complex forms macromolecular p...

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Detalles Bibliográficos
Autores principales:	Kunttas-Tatli, Ezgi, Roberts, David M., McCartney, Brooke M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214788/ https://www.ncbi.nlm.nih.gov/pubmed/25208568 http://dx.doi.org/10.1091/mbc.E14-04-0885

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