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Involvement of Class II Phosphoinositide 3-Kinase α-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells

In this study, we present findings that suggest that PI3K-C2α, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process of FcεRI-triggered degranulation. RBL-2H3 cells were transfected with shRNA targeting PI3K-C2α. The knockdown impaired the FcεRI-induced release o...

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Detalles Bibliográficos
Autores principales:	Nigorikawa, Kiyomi, Hazeki, Kaoru, Guo, Ying, Hazeki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214793/ https://www.ncbi.nlm.nih.gov/pubmed/25357130 http://dx.doi.org/10.1371/journal.pone.0111698

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