CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

In rhesus macaques (RMs), experimental depletion of CD4(+) T-cells prior to SIV infection results in higher viremia and emergence of CD4-independent SIV-envelopes. In this study we used the rhesus recombinant anti-CD4 antibody CD4R1 to deplete RM CD4(+) T-cells prior to SIVmac(251) infection and inv...

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Detalles Bibliográficos
Autores principales: Micci, Luca, Alvarez, Xavier, Iriele, Robin I., Ortiz, Alexandra M., Ryan, Emily S., McGary, Colleen S., Deleage, Claire, McAtee, Brigitte B., He, Tianyu, Apetrei, Cristian, Easley, Kirk, Pahwa, Savita, Collman, Ronald G., Derdeyn, Cynthia A., Davenport, Miles P., Estes, Jacob D., Silvestri, Guido, Lackner, Andrew A., Paiardini, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214815/
https://www.ncbi.nlm.nih.gov/pubmed/25356757
http://dx.doi.org/10.1371/journal.ppat.1004467

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