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Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population

PURPOSE: Exhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderl...

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Autores principales: Jo, Eun-Jung, Song, Woo-Jung, Kim, Tae-Wan, Park, Heung-Woo, Chang, Yoon-Seok, Kim, Tae-Bum, Kim, Sang-Heon, Hur, Gyu-Young, Lee, Jae-Hyung, Yoon, Ho-Joo, Park, Hae-Sim, Cho, Nam-Ho, Moon, Hee-Bom, Min, Kyung-Up, Cho, Sang-Heon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214970/
https://www.ncbi.nlm.nih.gov/pubmed/25374749
http://dx.doi.org/10.4168/aair.2014.6.6.504
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author Jo, Eun-Jung
Song, Woo-Jung
Kim, Tae-Wan
Park, Heung-Woo
Chang, Yoon-Seok
Kim, Tae-Bum
Kim, Sang-Heon
Hur, Gyu-Young
Lee, Jae-Hyung
Yoon, Ho-Joo
Park, Hae-Sim
Cho, Nam-Ho
Moon, Hee-Bom
Min, Kyung-Up
Cho, Sang-Heon
author_facet Jo, Eun-Jung
Song, Woo-Jung
Kim, Tae-Wan
Park, Heung-Woo
Chang, Yoon-Seok
Kim, Tae-Bum
Kim, Sang-Heon
Hur, Gyu-Young
Lee, Jae-Hyung
Yoon, Ho-Joo
Park, Hae-Sim
Cho, Nam-Ho
Moon, Hee-Bom
Min, Kyung-Up
Cho, Sang-Heon
author_sort Jo, Eun-Jung
collection PubMed
description PURPOSE: Exhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults. METHODS: For reference levels, we analyzed the baseline data of healthy adult participants in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO®. The characterization of the subjects was performed through structured questionnaires, spirometry, and methacholine challenge tests. To validate the diagnostic utility of the determined reference levels, asthma patients were recruited from medical institutions for FeNO measurement. RESULTS: A total of 570 healthy subjects were analyzed (mean age, 59.9±12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2±10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1±6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing asthma. The optimal cutoff values for the prediction of asthma were 30.5 ppb for males and 20.5 ppb for females. CONCLUSIONS: The current analysis presented reference ranges and the diagnostic utility of FeNO levels for asthma in Korean elderly adults.
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spelling pubmed-42149702014-11-05 Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population Jo, Eun-Jung Song, Woo-Jung Kim, Tae-Wan Park, Heung-Woo Chang, Yoon-Seok Kim, Tae-Bum Kim, Sang-Heon Hur, Gyu-Young Lee, Jae-Hyung Yoon, Ho-Joo Park, Hae-Sim Cho, Nam-Ho Moon, Hee-Bom Min, Kyung-Up Cho, Sang-Heon Allergy Asthma Immunol Res Original Article PURPOSE: Exhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults. METHODS: For reference levels, we analyzed the baseline data of healthy adult participants in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO®. The characterization of the subjects was performed through structured questionnaires, spirometry, and methacholine challenge tests. To validate the diagnostic utility of the determined reference levels, asthma patients were recruited from medical institutions for FeNO measurement. RESULTS: A total of 570 healthy subjects were analyzed (mean age, 59.9±12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2±10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1±6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing asthma. The optimal cutoff values for the prediction of asthma were 30.5 ppb for males and 20.5 ppb for females. CONCLUSIONS: The current analysis presented reference ranges and the diagnostic utility of FeNO levels for asthma in Korean elderly adults. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2014-11 2014-03-31 /pmc/articles/PMC4214970/ /pubmed/25374749 http://dx.doi.org/10.4168/aair.2014.6.6.504 Text en Copyright © 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jo, Eun-Jung
Song, Woo-Jung
Kim, Tae-Wan
Park, Heung-Woo
Chang, Yoon-Seok
Kim, Tae-Bum
Kim, Sang-Heon
Hur, Gyu-Young
Lee, Jae-Hyung
Yoon, Ho-Joo
Park, Hae-Sim
Cho, Nam-Ho
Moon, Hee-Bom
Min, Kyung-Up
Cho, Sang-Heon
Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title_full Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title_fullStr Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title_full_unstemmed Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title_short Reference Ranges and Determinant Factors for Exhaled Nitric Oxide in a Healthy Korean Elderly Population
title_sort reference ranges and determinant factors for exhaled nitric oxide in a healthy korean elderly population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214970/
https://www.ncbi.nlm.nih.gov/pubmed/25374749
http://dx.doi.org/10.4168/aair.2014.6.6.504
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