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The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea

OBJECTIVES: Measurement of the incidence of the human immunodeficiency virus (HIV) is very important for epidemiological studies. Here, we determined the recency period with the AxSYM avidity assay and the BED-capture enzyme immunoassay (BED-CEIA) in Korean seroconverters. METHODS: Two hundred longi...

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Autores principales: Yu, Hye-Kyung, Heo, Tae-Young, Kim, Na-Young, Wang, Jin-Sook, Lee, Jae-Kyeong, Kim, Sung Soon, Kee, Mee-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214998/
https://www.ncbi.nlm.nih.gov/pubmed/25379368
http://dx.doi.org/10.1016/j.phrp.2014.06.002
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author Yu, Hye-Kyung
Heo, Tae-Young
Kim, Na-Young
Wang, Jin-Sook
Lee, Jae-Kyeong
Kim, Sung Soon
Kee, Mee-Kyung
author_facet Yu, Hye-Kyung
Heo, Tae-Young
Kim, Na-Young
Wang, Jin-Sook
Lee, Jae-Kyeong
Kim, Sung Soon
Kee, Mee-Kyung
author_sort Yu, Hye-Kyung
collection PubMed
description OBJECTIVES: Measurement of the incidence of the human immunodeficiency virus (HIV) is very important for epidemiological studies. Here, we determined the recency period with the AxSYM avidity assay and the BED-capture enzyme immunoassay (BED-CEIA) in Korean seroconverters. METHODS: Two hundred longitudinal specimens from 81 seroconverters with incident HIV infections that had been collected at the Korea National Institute of Health were subjected to the AxSYM avidity assay (cutoff = 0.8) and BED-CEIA (cutoff = 0.8). The statistical method used to estimate the recency period in recent HIV infections was nonparametric survival analyses. Sensitivity and specificity were calculated for 10-day increments from 120 days to 230 days to determine the recency period. RESULTS: The mean recency period of the avidity assay and BED-CEIA using a survival method was 158 days [95% confidence interval (CI), 135–181 days] and 189 days (95% CI, 170–208 days), respectively. Based on the use of sensitivity and specificity, the mean recency period for the avidity assay and BED-CEIA was 150 days and 200 days, respectively. CONCLUSION: We determined the recency period to estimate HIV incidence in Korea. These data showed that the nonparametric survival analysis often led to shorter recency periods than analysis of sensitivity and specificity as a new method. These findings suggest that more data from seroconverters and other methodologies are needed to determine the recency period for estimating HIV incidence.
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spelling pubmed-42149982014-11-06 The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea Yu, Hye-Kyung Heo, Tae-Young Kim, Na-Young Wang, Jin-Sook Lee, Jae-Kyeong Kim, Sung Soon Kee, Mee-Kyung Osong Public Health Res Perspect Original Article OBJECTIVES: Measurement of the incidence of the human immunodeficiency virus (HIV) is very important for epidemiological studies. Here, we determined the recency period with the AxSYM avidity assay and the BED-capture enzyme immunoassay (BED-CEIA) in Korean seroconverters. METHODS: Two hundred longitudinal specimens from 81 seroconverters with incident HIV infections that had been collected at the Korea National Institute of Health were subjected to the AxSYM avidity assay (cutoff = 0.8) and BED-CEIA (cutoff = 0.8). The statistical method used to estimate the recency period in recent HIV infections was nonparametric survival analyses. Sensitivity and specificity were calculated for 10-day increments from 120 days to 230 days to determine the recency period. RESULTS: The mean recency period of the avidity assay and BED-CEIA using a survival method was 158 days [95% confidence interval (CI), 135–181 days] and 189 days (95% CI, 170–208 days), respectively. Based on the use of sensitivity and specificity, the mean recency period for the avidity assay and BED-CEIA was 150 days and 200 days, respectively. CONCLUSION: We determined the recency period to estimate HIV incidence in Korea. These data showed that the nonparametric survival analysis often led to shorter recency periods than analysis of sensitivity and specificity as a new method. These findings suggest that more data from seroconverters and other methodologies are needed to determine the recency period for estimating HIV incidence. 2014-06-28 2014-08 /pmc/articles/PMC4214998/ /pubmed/25379368 http://dx.doi.org/10.1016/j.phrp.2014.06.002 Text en © 2014 Published by Elsevier B.V. on behalf of Korea Centers for Disease Control and Prevention. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Original Article
Yu, Hye-Kyung
Heo, Tae-Young
Kim, Na-Young
Wang, Jin-Sook
Lee, Jae-Kyeong
Kim, Sung Soon
Kee, Mee-Kyung
The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title_full The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title_fullStr The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title_full_unstemmed The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title_short The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
title_sort recency period for estimation of human immunodeficiency virus incidence by the axsym avidity assay and bed-capture enzyme immunoassay in the republic of korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214998/
https://www.ncbi.nlm.nih.gov/pubmed/25379368
http://dx.doi.org/10.1016/j.phrp.2014.06.002
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