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Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii

BACKGROUND: Thiamine (vitamin B1) is synthesized de novo by certain yeast, fungi, plants, protozoans, bacteria and archaea. The pathway of thiamine biosynthesis by archaea is poorly understood, particularly the route of sulfur relay to form the thiazole ring. Archaea harbor structural homologs of bo...

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Detalles Bibliográficos
Autores principales:	Hwang, Sungmin, Cordova, Bryan, Chavarria, Nikita, Elbanna, Dina, McHugh, Stephen, Rojas, Jenny, Pfeiffer, Friedhelm, Maupin-Furlow, Julie A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215014/ https://www.ncbi.nlm.nih.gov/pubmed/25348237 http://dx.doi.org/10.1186/s12866-014-0260-0

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