Porcine SLITRK1: Molecular cloning and characterization

The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns...

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Autores principales: Larsen, Knud, Momeni, Jamal, Farajzadeh, Leila, Bendixen, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215120/
https://www.ncbi.nlm.nih.gov/pubmed/25379384
http://dx.doi.org/10.1016/j.fob.2014.10.001
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author Larsen, Knud
Momeni, Jamal
Farajzadeh, Leila
Bendixen, Christian
author_facet Larsen, Knud
Momeni, Jamal
Farajzadeh, Leila
Bendixen, Christian
author_sort Larsen, Knud
collection PubMed
description The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues.
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spelling pubmed-42151202014-11-06 Porcine SLITRK1: Molecular cloning and characterization Larsen, Knud Momeni, Jamal Farajzadeh, Leila Bendixen, Christian FEBS Open Bio Article The membrane protein SLITRK1 functions as a developmentally regulated stimulator of neurite outgrowth and variants in this gene have been implicated in Tourette syndrome. In the current study we have cloned and characterized the porcine SLITRK1 gene. The genomic organization of SLITRK1 lacks introns, as does its human and mouse counterparts. RT-PCR cloning revealed two SLITRK1 transcripts: a full-length mRNA and a transcript variant that results in a truncated protein. The encoded SLITRK1 protein, consisting of 695 amino acids, displays a very high homology to human SLITRK1 (99%). The porcine SLITRK1 gene is expressed exclusively in brain tissues. Elsevier 2014-10-07 /pmc/articles/PMC4215120/ /pubmed/25379384 http://dx.doi.org/10.1016/j.fob.2014.10.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Larsen, Knud
Momeni, Jamal
Farajzadeh, Leila
Bendixen, Christian
Porcine SLITRK1: Molecular cloning and characterization
title Porcine SLITRK1: Molecular cloning and characterization
title_full Porcine SLITRK1: Molecular cloning and characterization
title_fullStr Porcine SLITRK1: Molecular cloning and characterization
title_full_unstemmed Porcine SLITRK1: Molecular cloning and characterization
title_short Porcine SLITRK1: Molecular cloning and characterization
title_sort porcine slitrk1: molecular cloning and characterization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215120/
https://www.ncbi.nlm.nih.gov/pubmed/25379384
http://dx.doi.org/10.1016/j.fob.2014.10.001
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AT bendixenchristian porcineslitrk1molecularcloningandcharacterization

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